ac-11® Cat's Claw Inner Bark Extract 700 mg 3-Pack
Clinically-Studied Ingredient for DNA Repair
700 mg, 30 vegetarian capsules
AC-11® — the patented ingredient for DNA repair, immune support, and enhanced collagen production.
Lab Tested | Gluten free | Non-GMO | Junk Free
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Combat aging at the cellular level!
Boost your immune system, promote the production of Type-III collagen, repair DNA damage, and more with ac-11® Cat’s Claw.
ac-11® benefits at a glance:
- Age-defying DNA Repair: ac-11® Cat's Claw helps combat accelerated aging by supporting your body’s natural ability to repair its DNA.
- Youthful Skin: Increases production of type-III collagen for soft, supple, and youthful-looking skin.
- Immune Boosting Power: Strengthens your immune system by increasing the life cycle of white blood cells.
- Support Inflammation Response: Promotes a healthy response to inflammation.
- Telomere Health: Maintains telomere length and integrity during cellular mitosis for optimal cellular health.
- Neural Repair & Protection: Repairs and protects neural function damaged by overexposure to high-decibel noise.
Introducing AC-11®: The Revolutionary Supplement That Helps Your Body’s Repair DNA & Supercharges Immune Function at the Cellular Level
Want to prevent accelerated aging by clearing junk from your cells and repairing your DNA? Looking to boost collagen to maintain skin and joint health? How about a solution to supercharge your immune function against today’s health challenges? Look no further than AC-11®, the breakthrough anti-aging supplement from Proof Vitality.
What Is AC-11®?
It’s a powerful and patented extract of the Uncaria Tomentosa inner bark, also known as Cat’s Claw. AC-11® is backed by 42 published clinical studies that demonstrate its remarkable ability to boost collagen production, provide powerful daily immune support, and promote longevity. This unique supplement contains carboxy alkyl esters (CAEs), natural compounds that help your body fight back against the effects of normal aging.
But what truly distinguishes AC-11® is its ability to support DNA and cell repair. By enhancing the body’s natural DNA repair mechanism, AC-11® combats accelerated aging and helps your body maintain telomere length and integrity during cellular division. This means that AC-11® can assist in rejuvenating all of your cells, making you look and feel more youthful and vibrant.
In addition to bolstering immunity and enhancing skin health, AC-11® improves tissue and organ function by clearing out damaged cells and combating inflammation. It’s the ultimate solution for anyone seeking to restore their youthful vitality and enhance overall health and well-being.
Why Should I Take AC-11®?
Take AC-11® for three critical reasons: to defend your body against one of the most significant mechanisms of aging—damaged cells and DNA, to boost collagen production for enhanced skin health, and to provide your body with deep immune support for today’s immune challenges. While aging is inevitable, providing your body with the right support is key.
Without this support, your body’s ability to repair itself becomes limited. As we age, this self-repairing capacity becomes even less effective. Consequently, cells replicate in a damaged or corrupted form, compromising cell division to the extent that it may no longer be possible.
This weakened cellular function can lead to chronic inflammation, disease, illness, and accelerated aging. But that’s not all; it can also cause your youthful collagen to deteriorate, resulting in wrinkled skin and weaker bones and stiffer joints.
AC-11® is a science-based ingredient that combats this process by clearing cellular debris and aiding your body in repairing its DNA. This enhancement extends to the function of organs, tissues (including collagen and skin), and muscles.
Protect your cells and DNA from the effects of normal aging. Give AC-11® from Proof Vitality a try today.
A Deep Dive on AC-11® Benefits
ac-11® is a unique nutritional supplement with a long history of clinical research. Backed by 42 clinical studies, few supplements have been researched as extensively as ac-11® for DNA repair and lifespan, collagen support and skin elasticity, immune function, cognitive health, and more.
By helping your body combat accelerated aging and supporting whole-body health, ac-11® promotes natural DNA repair and telomere repair. It also helps clear out damaged cells, inhibits inflammatory factors, and boosts immune function.
Discover the compelling benefits of the Amazon miracle, ac-11®:
Promotes Natural DNA Repair & Telomere Repair
As we age, our DNA can become damaged due to environmental factors such as pollution, UV radiation, and processed foods. This damage can lead to physical signs of aging and serious diseases such as cancer. ac-11® helps your body combat this natural process of aging by promoting natural DNA repair and telomere repair. Studies suggest ac-11® may help your body repair and maintain its DNA, combating accelerated aging.
Boosts Type III Collagen Production & Promotes Skin Health
Youthful skin is supple and elastic due to the presence of type III collagen. Studies show that ac-11® significantly boosts the natural production of type III collagen in cutaneous tissue during periods of sun exposure, promoting healthy, youthful-looking skin.
Enhances Immune Function
Several studies have shown that a daily dosage of 700 mg of ac-11® may increase your white blood cell count, enhancing your immune response to combat infections and viruses. Additionally, ac-11® promotes a healthy response to inflammation, which may help regulate your immune function and prevent your immune system from overreacting.
Promotes a Healthy Inflammation Response
Inflammation is a natural response to injury or infection, but chronic inflammation can lead to serious health issues. Studies show that ac-11® may help normalize the expression of the NF-kB factor in cells, promoting a healthy response to inflammation. By supporting apoptosis, or programmed cell death, ac-11® helps your body clear out damaged cells and promote the replication of healthy cells.
Repairs Neural Damage from Overexposure to High-Decibel Noise
Loud music and high-decibel noise can cause neural damage over time. ac-11® helps your body repair neural function that has been damaged due to overexposure to high-decibel noise.
Clinically Proven
ac-11® has been the subject of 42 clinical studies, which have shown that it protects the body against the normal effects of aging by helping your body repair its own DNA. Furthermore, ac-11® boosts general health and vitality by supporting a healthy response to inflammation, enhancing immune function, boosting type III collagen production, and promoting skin elasticity.
Incorporating ac-11® into your daily routine can help you combat the effects of aging, enhance your immune function, and promote healthy skin and neural function. Try ac-11® today and experience the age-defying benefits for yourself.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Frequently Asked Questions
AC-11® Cat's Claw
ac-11® is a safe, all-natural, and highly-effective aqueous extract of Cat’s Claw (Uncaria tomentosa), a traditional medicinal plant indigenous to the Amazon rainforest. ac-11® is radically different than other cat’s claw exctracts since it is practically free of alkaloids. Standardized to a minimum 8% Carboxy Alkyl Esters (CAEs), research demonstrates ac-11®’s natural ability to help the body repair its DNA. Additional studies have also shown ac-11®’s ability to: support your body’s inflammation response, help rid the body of damaged cells, enhance immune function, and decrease the rate of telomere truncation.
Yes. Currently, ac-11® is backed by 42 clinical studies demonstrating its efficacy in oral and topical applications.
DNA (deoxyribonucleic acid) is the self-replicating molecule containing the genetic instructions for the functioning, development, growth, and reproduction of nearly all living organisms.
Absolutely. DNA contains genetic instructions driving all processes within the body and is critical to the optimal functioning of all cells within the body. Damage to DNA results in cellular mutation, resulting in the inefficient functioning of critical biological processes within the body. Evidence has shown that DNA damage is a key contributor to accelerated aging and may be linked to age-onset disease.
Natural DNA Repair is driven by several enzymatic processes that clear the damage caused to our DNA by oxidative and non-oxidative stress. Genetic integrity and cellular function are optimized and preserved by the homeostatic processes involved in natural DNA repair – keeping your body in its natural equilibrium. Consequently, the better our DNA repair processes work, the longer and healthier our lives can be.
Aging is the natural time-related deterioration of the body’s biological functions necessary to efficiently clear cellular toxicity and repair damaged DNA. The accumulation of DNA damage results in signs of aging, such as wrinkled or sagging skin, cognitive decline, and weakened immune function.
Not absolutely. Our DNA does not mean that we will age exactly like our family members. It also doesn’t mean that we will necessarily suffer the same genetic-related diseases. We can avoid detrimental lifestyle and environmental hazards that may contribute to accelerated aging or trigger the onset of certain genetically-based diseases. Avoiding overexposure to the sun, cigarette smoking, excessive alcohol consumption, and exposure to toxic environmental pollutants to help reduce cellular damage. Eating a diet rich in antioxidants, managing daily stress, and supplementing nutritional intake in smart ways can help minimize damage to DNA that takes place every day and improve the built-in repair mechanisms in our cells.
However, the damage to cells and DNA that has already occurred cannot be repaired. ac-11® is the first and only known plant extract shown to improve your body’s DNA repair ability.
ac-11® helps your body’s natural ability to repair its DNA. ac-11® may activate critical DNA repair enzymes located on Chromosome 11 that facilitate the body’s natural DNA repair process.
Backed by 42 clinical studies (and counting), ac-11® has been shown to have numerous therapeutic benefits including but not limited to:
- Support the body’s natural ability to repair its DNA—combating accelerated aging
- Repair skin damage resulting from excessive exposure to the Sun
- Boost immune function by increasing the life cycle of white blood cells
- Repair neural function damage caused by overexposure to high-decibel noise
- Promote a healthy response to inflammation resulting in the down-regulation of pro-inflammatory cytokines
- Maintain telomere length and integrity during cellular mitosis
- Enhance the production of natural collagen III—a form of collagen associated with soft, supple, youthful-looking skin
Lab Tested | Gluten free | Non-GMO | Junk Fee
ac-11® is the only known extract of Uncaria tomentosa that helps the body repair its DNA. This therapeutic claim is demonstrated by 42 clinical studies and a variety of patents. ac-11® has a distinctly low-weight, alkaloid-free molecular composition that’s extremely small (less than 10,000 Daltons) and is highly bioavailable due to its patented ultra-filtration aqueous extraction process. As a result, ac-11® is safe, pure, and effective for long-term use.
Contrarily, the other generic “cat’s claw” extracts on the market are not grounded in research. They are most are water-insoluble, alkaloid-based extracts and are shown to be mildly toxic with long-term use.
ac-11® is produced in an ISO 9002-Certified Facility operated under strict FDA regulations and GMP (Good Manufacturing Practices) standards. Lab Tested, ac-11® adheres to all accepted industry standards to ensure the safety, purity, and efficacy of every batch.
Yes. ac-11® consumption has been proven to be safe at any amount less than 8,000mg. The recommended daily dose of ac-11® is 350 to 700mg for adults weighing between 120 and 200 pounds (70-90 kg).
We recommend consulting your healthcare practitioner is you are pregnant, nursing or on medication. However, ac-11® does not negatively interact with common pharmaceuticals and is safe to take with other medications as has been demonstrated by CYP analysis.
Yes. ac-11® has 11 patents protecting its technology, composition, active ingredients, and numerous health benefits.
No. ac-11® and its carrier, Manioc Maltodextrin, are all-natural.
Yes. ac-11® is made in full cooperation with the Floravida Institutes of Brazil’s guidelines for biodiversity, environmental education, conservation, and local community social inclusion. ac-11®, extracted from the inner bark of Cat’s Claw (Uncaria tomentosa), is sustainably harvested around three feet above the ground to maintain the plant’s health. Then, to further promote the integrity of the root structure and to stimulate rapid regeneration of the vine, the plant is capped. Finally, new Cat’s Claw seedlings are carefully planted in the harvesting zone to ensure continued viability.
References
DNA Repair, Cellular Health, Anti Aging, Life Span, & Health Span
1. Sheng Y, Li L, Holmgren K, Pero RW. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001 Jul;8(4):275-82. doi: 10.1078/0944-7113-00045. PMID: 11515717.
2. Pero, R. W., Hoppe, C., & Sheng, Y. (2000). Serum Thiols as a Surrogate Estimate of DNA Repair Correlates to Mammalian Life Span. Journal of Anti-Aging Medicine. https://doi.org/10.1089/rej.1.2000.3.241
3. Banne AF, Amiri A, Pero RW. Reduced level of serum thiols in patients with a diagnosis of active disease. J Anti Aging Med. 2003;6(4):327-34. doi: 10.1089/109454503323028920. PMID: 15142434.
4. Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18. PMID: 22706308; PMCID: PMC3386805.
5. Akesson Ch, Pero RW, Ivars F. C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine. 2003 Jan;10(1):23-33. doi: 10.1078/094471103321648629. PMID: 12622460.
6. Pero RW, Amiri A, Sheng Y, Welther M, Rich M. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. Phytomedicine. 2005 Apr;12(4):255-63. doi: 10.1016/j.phymed.2004.01.008. PMID: 15898702.
7. Pero, R. W., Giampapa, V. C., & Vojdani, A. (2002). Comparison of a Broad Spectrum Anti-Aging Nutritional Supplement with and without the Addition of a DNA Repair Enhancing Cat’s Claw Extract. Journal of Anti-Aging Medicine. https://doi.org/10.1089/109454502763485467
8.Pero, R. W. (2009, September 1). In vivo treatment of humans with quinic acid enhances DNA repair and reduces the influence of lifestyle factors on risk to disease. Document – Gale Academic OneFile. https://go.gale.com/ps/i.do?id=GALE%7CA215925274&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=09732691&p=AONE&sw=w&userGroupName=anon%7E6ddd846
9. Guthrie OW. Dynamic compartmentalization of DNA repair proteins within spiral ganglion neurons in response to noise stress. Int J Neurosci. 2012 Dec;122(12):757-66. doi: 10.3109/00207454.2012.721828. Epub 2012 Oct 16. PMID: 22900489.
Immune Health, Inflammation Response, Apoptosis, & Cellular Senescence
10. Sheng Y, Pero RW, Amiri A, Bryngelsson C. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Res. 1998 Sep-Oct;18(5A):3363-8. PMID: 9858909.
11. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000 Feb;69(2):115-26. doi: 10.1016/s0378-8741(99)00070-7. PMID: 10687868.
12. Sheng Y, Pero RW, Wagner H. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000 Apr;7(2):137-43. doi: 10.1016/S0944-7113(00)80086-0. PMID: 10839217.
13. Lamm S, Sheng Y, Pero RW. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine. 2001 Jul;8(4):267-74. doi: 10.1078/0944-7113-00046. PMID: 11515716.
Brain Health, Neurological Support, Cognitive Function, Hearing
14. Guthrie OW, Gearhart CA, Fulton S, Fechter LD. Carboxy alkyl esters of Uncaria tomentosa augment recovery of sensorineural functions following noise injury. Brain Res. 2011 Aug 17;1407:97-106. doi: 10.1016/j.brainres.2011.06.044. Epub 2011 Jun 24. PMID: 21762882.
15. Guthrie, O. W., & Xu, H. (2013b). Reduced Phosphorylation of Histone Variant H2Ax in the Organ of Corti is Associated with Otoprotection from Noise Injury. Otolaryngology, 03(01). https://doi.org/10.4172/2161-119x.1000131
16. Guthrie OW. Preservation of Neural Sensitivity after Noise-Induced Suppression of Sensory Function. J Am Acad Audiol. 2016 Jan;27(1):49-61. doi: 10.3766/jaaa.15047. PMID: 26809326.
17. Shi Z, Lu Z, Zhao Y, Wang Y, Zhao-Wilson X, Guan P, Duan X, Chang YZ, Zhao B. Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model. Neurochem Int. 2013 Jun;62(7):940-7. doi: 10.1016/j.neuint.2013.03.001. Epub 2013 Mar 14. PMID: 23500604.
Safety, Efficacy, Functionality
18. Montoro P, Carbone V, Quiroz Jde D, De Simone F, Pizza C. Identification and quantification of components in extracts of Uncaria tomentosa by HPLC-ES/MS. Phytochem Anal. 2004 Jan-Feb;15(1):55-64. doi: 10.1002/pca.740. PMID: 14979528.
19. Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F. Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100. Int Immunopharmacol. 2005 Jan;5(1):219-29. doi: 10.1016/j.intimp.2004.09.028. PMID: 15589483.
20. Sheng Y, Akesson C, Holmgren K, Bryngelsson C, Giamapa V, Pero RW. An active ingredient of Cat’s Claw water extracts identification and efficacy of quinic acid. J Ethnopharmacol. 2005 Jan 15;96(3):577-84. doi: 10.1016/j.jep.2004.10.002. Epub 2004 Dec 8. PMID: 15619581.
21. Historical Development of Uncaria Preparations and Their Related bioactive Components. novapublishers.com.(Pero: Nova Sciences Publishers, Chapter 10, 2010)
22. McDonnell AM, Dang CH. Basic review of the cytochrome p450 system. J Adv Pract Oncol. 2013 Jul;4(4):263-8. doi: 10.6004/jadpro.2013.4.4.7. PMID: 25032007; PMCID: PMC4093435.
Antioxidant Potential
23. Brunswick Labs, Certificate of Analysis, ORAC Value results for ac-11®
24. Pero RW, Lund H, Leanderson T. Antioxidant metabolism induced by quinic acid. Increased urinary excretion of tryptophan and nicotinamide. Phytother Res. 2009 Mar;23(3):335-46. doi: 10.1002/ptr.2628. PMID: 18844285.
25. Pero RW, Lund H. Dietary quinic acid supplied as the nutritional supplement AIO + AC-11® leads to induction of micromolar levels of nicotinamide and tryptophan in the urine. Phytother Res. 2011 Jun;25(6):851-7. doi: 10.1002/ptr.3348. Epub 2010 Nov 22. PMID: 21104945.