ac-11® + Pycnogenol® Bundle
Combat Accelerated Aging at the Cellular Level with Patented Ingredients Backed by Science.
Advanced DNA Repair? Enhanced Microcirculation? Immune Support and Inflammation Management? Our Bundle has it all. Get science-based ingredients you cant trust for a healthier you. Order now.
Lab Tested | Gluten free | Non-GMO | Junk Free
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Fight Back Against Accelerated Aging at the Cellular Level!
Maintain the Health of Your Skin, Brain, Heart, and Immune Function with Patented Ingredients (ac-11® and Pycnogenol®). Experience more than a dozen combined benefits to help you look and feel your best. Get the ac-11® + Pycnogenol® Bundle today.
Benefits at a glance:
- Age-defying DNA Repair & Telomere Health: Combats accelerated aging by supporting your body’s natural ability to repair its DNA and maintain telomere length and integrity during cellular division.
- Youthful Skin: Boosts type-III collagen and hyaluronic acid synthesis, skin elasticity, and hydration while reducing skin fatigue and pigmentation and limiting photo-aging.
- Brain Health: Improves memory, enhances cognitive function, and reduces test anxiety.
- Heart Health: Supports healthy circulatory and endothelial function and boosts nitric oxide levels.
- Immune Boosting Power: Boost immune function by increasing the life cycle of white blood cells and lowering oxidative stress.
- Support Inflammation Response: Reduces oxidative stress and maintains overall wellness.
Bundle Overview:
What are ac-11® and Pycnogenol®?
Looking to turn back the clock on aging and enhance your overall health? Look no further than the ac-11® and Pycnogenol® bundle! This dynamic duo packs a powerful punch, offering a comprehensive approach to health and wellness.
First up is ac-11®, the patented extract of Uncaria Tomentosa inner bark that has been validated by an impressive 42 published clinical studies. This ingredient is the only one of its kind that has been shown to help your body repair its own DNA, which is critical for collagen health, immune health, and longevity.
But that’s not all – the Pycnogenol® component of this bundle is equally impressive. Backed by 160 clinical studies and 70 human clinical trials, Pycnogenol® delivers all-system support by promoting a healthy response to inflammation, boosting immune function, enhancing circulation and heart health, increasing muscle endurance, sharpening vision, and enhancing your skin’s beauty
In combination, ac-11® and Pycnogenol® provide a powerful one-two punch that will help you feel and look your best. Say goodbye to accelerated aging and hello to beautiful, youthful skin, boosted immune function, enhanced circulation, and overall better health. With science-based ingredients you can trust, this bundle is a must-have for anyone looking to take their
Why Should I Get the ac-11® + Pycnogenol® Bundle?
Looking for supplements that promote healthy aging, boost collagen and skin elasticity, support the immune system, and enhance cognitive function? Look no further than our ac-11® + Pycnogenol® bundle. With over 202 clinical studies and 70+ human clinical trials, this powerful combination of natural ingredients has been extensively researched for its numerous health benefits.
ac-11® helps combat accelerated aging by supporting DNA repair and immune function, while also inhibiting inflammatory factors. It can also aid in repairing neural function caused by overexposure to high-decibel noise. Meanwhile, Pycnogenol® promotes healthy circulation and supports vascular health. It is a powerful antioxidant that inhibits inflammatory factors and helps to maintain healthy glucose levels.
But that’s not all—Pycnogenol® has been shown to improve cognitive function, enhance memory and test scores, and stimulate collagen synthesis to improve skin health. It also supports vision and hearing health and promotes healthy inflammatory and immune responses.
Experience the benefits of ac-11® and Pycnogenol® for yourself. With this powerful bundle, you can support whole-body health, repair your DNA, boost your immune system, enhance your cognitive function, and feel and look your best. Don’t wait any longer to invest in your well-being – try our ac-11® + Pycnogenol® Bundle and take the first step towards a healthier, happier you!
Bundle Benefits:Want to take a deeper dive? Read on!
Introducing ac-11® and Pycnogenol®, the ultimate health and wellness combo backed by over 202 clinical studies and 70 human trials. These patented ingredients have been extensively researched and proven to provide numerous health benefits such as DNA repair, collagen support, skin elasticity, immune function, cognitive health, healthy circulation, and more.
Discover the comprehensive benefits of ac-11® and Pycnogenol® and elevate your health to new heights with this scientifically-proven bundle.
Natural DNA Repair & Telomere Repair
ac-11® supports DNA repair, a critical factor in combating accelerated aging caused by environmental factors like pollution, radiation, and processed foods. It aids in inhibiting inflammation, clearing damaged cells, and boosting immune function, potentially slowing down the aging process. A dosage of up to 700mg may help your body combat this natural process called aging.
Skin Care & Collagen Support
ac-11® significantly boosts the natural production of type-III collagen, giving youthful skin its suppleness and elasticity. Pycnogenol® stimulates collagen synthesis, enhances skin elasticity, and moisturizes the skin while inhibiting the break-down of collagen and elastin, protecting your skin and reducing pigmentation for a bright and even complexion.
Antioxidant & Blood Sugar Support
Pycnogenol® helps maintain already-healthy glucose levels and supports the body’s antioxidant defenses with powerful phytonutrient compounds, inhibiting free-radical activity that can damage cells, tissue, organs, and DNA.
Brain Health, Cognition, & Memory
Pycnogenol® French maritime pine bark extract improves cognitive function and enhances numerical and spatial working memory. It also improves memory and test scores in college students, improving mental performance and decreasing test anxiety by 17%.
Vision & Hearing
ac-11® helps repair neural function caused by damage due to overexposure to high-decibel noise, while Pycnogenol® supports eye health by acting as a potent free radical scavenger, protecting retinal lipids, and enhancing endothelial function of the retinal microvessels, supporting micro-circulation in the retina.
Heart, Circulatory, & Arterial Health
Pycnogenol® supports endothelial and arterial health, encouraging healthy nitric oxide levels in the arteries, promoting a healthy inflammatory response and platelet function, and helping to inhibit inflammatory factors called cytokines.
Respiratory, Allergy, Immune Health & Inflammation Response
AC-11 has been shown to enhance the immune response and combat infections and viruses by increasing white blood cell count. It has also been found to promote a healthy response to inflammation, regulating immune function and preventing overreactions. AC-11 normalizes the expression of the NF-kB factor in cells, promoting healthy inflammation response, and supporting the clearance of damaged cells and the replication of healthy cells. Pycnogenol helps combat inflammation and normalize immune response by inhibiting the immune cell that triggers inflammation. It also promotes a healthy response to histamine, preventing the release of histamine from irritated mast cells and protecting the body from allergies and respiratory infections.
Men’s Health
Pycnogenol has been shown to significantly improve erectile function by promoting arterial relaxation and supporting healthy blood flow to the corpus cavernosum. It may also help counteract benign prostate enlargement and facilitate emptying of the bladder. Pycnogenol supports muscular function and endurance, stabilizing muscles through the natural aging process. It can also enhance athletic performance, speed up recovery, and reduce muscle harm during activity.
Women’s Health
Pycnogenol has been shown to significantly reduce abdominal discomfort and cramping in women during difficult menstrual periods. It decreases tenderness during menstruation and provides further relief after continued supplementation. Pycnogenol naturally reduces hot flashes, depression, panic attacks, and other common manifestations associated with women entering menopause transition.
Sports Nutrition
Pycnogenol supports an active lifestyle by protecting muscles from harm during activity, enhancing performance and endurance, and speeding up recovery. It helps the body get back in action faster, allowing athletes to maintain their active lifestyle for longer.
Clinically Proven
AC-11 helps repair the body’s DNA, protecting against the normal effects of aging. It also supports healthy inflammation response, enhances immune function, boosts type-III collagen production, and promotes skin elasticity. Pycnogenol is backed by 160 clinical studies and 70 human clinical trials, providing antioxidant support, enhancing skin health, promoting cardiovascular health, boosting immune function, supporting vision health, enhancing cognitive function, and more.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Frequently Asked Questions
AC-11® Cat's Claw Inner Bark Extract
ac-11® is a safe, all-natural, and highly-effective aqueous extract of Cat’s Claw (Uncaria tomentosa), a traditional medicinal plant indigenous to the Amazon rainforest. ac-11® is radically different than other cat’s claw exctracts since it is practically free of alkaloids. Standardized to a minimum 8% Carboxy Alkyl Esters (CAEs), research demonstrates ac-11®’s natural ability to help the body repair its DNA. Additional studies have also shown ac-11®’s ability to: support your body’s inflammation response, help rid the body of damaged cells, enhance immune function, and decrease the rate of telomere truncation.
Yes. Currently, ac-11® is backed by 42 clinical studies demonstrating its efficacy in oral and topical applications.
DNA (deoxyribonucleic acid) is the self-replicating molecule containing the genetic instructions for the functioning, development, growth, and reproduction of nearly all living organisms.
Absolutely. DNA contains genetic instructions driving all processes within the body and is critical to the optimal functioning of all cells within the body. Damage to DNA results in cellular mutation, resulting in the inefficient functioning of critical biological processes within the body. Evidence has shown that DNA damage is a key contributor to accelerated aging and may be linked to age-onset disease.
Natural DNA Repair is driven by several enzymatic processes that clear the damage caused to our DNA by oxidative and non-oxidative stress. Genetic integrity and cellular function are optimized and preserved by the homeostatic processes involved in natural DNA repair – keeping your body in its natural equilibrium. Consequently, the better our DNA repair processes work, the longer and healthier our lives can be.
Aging is the natural time-related deterioration of the body’s biological functions necessary to efficiently clear cellular toxicity and repair damaged DNA. The accumulation of DNA damage results in signs of aging, such as wrinkled or sagging skin, cognitive decline, and weakened immune function.
Not absolutely. Our DNA does not mean that we will age exactly like our family members. It also doesn’t mean that we will necessarily suffer the same genetic-related diseases. We can avoid detrimental lifestyle and environmental hazards that may contribute to accelerated aging or trigger the onset of certain genetically-based diseases. Avoiding overexposure to the sun, cigarette smoking, excessive alcohol consumption, and exposure to toxic environmental pollutants to help reduce cellular damage. Eating a diet rich in antioxidants, managing daily stress, and supplementing nutritional intake in smart ways can help minimize damage to DNA that takes place every day and improve the built-in repair mechanisms in our cells.
However, the damage to cells and DNA that has already occurred cannot be repaired. ac-11® is the first and only known plant extract shown to improve your body’s DNA repair ability.
ac-11® helps your body’s natural ability to repair its DNA. ac-11® may activate critical DNA repair enzymes located on Chromosome 11 that facilitate the body’s natural DNA repair process.
Backed by 42 clinical studies (and counting), ac-11® has been shown to have numerous therapeutic benefits including but not limited to:
- Support the body’s natural ability to repair its DNA—combating accelerated aging
- Repair skin damage resulting from excessive exposure to the Sun
- Boost immune function by increasing the life cycle of white blood cells
- Repair neural function damage caused by overexposure to high-decibel noise
- Promote a healthy response to inflammation resulting in the down-regulation of pro-inflammatory cytokines
- Maintain telomere length and integrity during cellular mitosis
- Enhance the production of natural collagen III—a form of collagen associated with soft, supple, youthful-looking skin
Lab Tested | Gluten free | Non-GMO | Junk Fee
ac-11® is the only known extract of Uncaria tomentosa that helps the body repair its DNA. This therapeutic claim is demonstrated by 42 clinical studies and a variety of patents. ac-11® has a distinctly low-weight, alkaloid-free molecular composition that’s extremely small (less than 10,000 Daltons) and is highly bioavailable due to its patented ultra-filtration aqueous extraction process. As a result, ac-11® is safe, pure, and effective for long-term use.
Contrarily, the other generic “cat’s claw” extracts on the market are not grounded in research. They are most are water-insoluble, alkaloid-based extracts and are shown to be mildly toxic with long-term use.
ac-11® is produced in an ISO 9002-Certified Facility operated under strict FDA regulations and GMP (Good Manufacturing Practices) standards. Lab Tested, ac-11® adheres to all accepted industry standards to ensure the safety, purity, and efficacy of every batch.
Yes. ac-11® consumption has been proven to be safe at any amount less than 8,000mg. The recommended daily dose of ac-11® is 350 to 700mg for adults weighing between 120 and 200 pounds (70-90 kg).
We recommend consulting your healthcare practitioner is you are pregnant, nursing or on medication. However, ac-11® does not negatively interact with common pharmaceuticals and is safe to take with other medications as has been demonstrated by CYP analysis.
Yes. ac-11® has 11 patents protecting its technology, composition, active ingredients, and numerous health benefits.
No. ac-11® and its carrier, Manioc Maltodextrin, are all-natural.
Yes. ac-11® is made in full cooperation with the Floravida Institutes of Brazil’s guidelines for biodiversity, environmental education, conservation, and local community social inclusion. ac-11®, extracted from the inner bark of Cat’s Claw (Uncaria tomentosa), is sustainably harvested around three feet above the ground to maintain the plant’s health. Then, to further promote the integrity of the root structure and to stimulate rapid regeneration of the vine, the plant is capped. Finally, new Cat’s Claw seedlings are carefully planted in the harvesting zone to ensure continued viability.
Pycnogenol® French Maritime Pine Bark Extract
Pycnogenol® is a natural plant extract originating from the bark of the maritime pine trees that grow along the coast of southwest France.
Pycnogenol® has been extensively studied for over 40 years to establish its safety, efficacy and quality. It is a unique combination of procyanidins, bioflavonoids and phenolic acids that offer a wide range of natural health benefits.
With over 160 clinical trials and 450 scientific publications, Pycnogenol® has been proven to be a safe and effective ingredient for men and women.
Yes. Pycnogenol® sets the bar for evidence-based supplements with over 150 clinical studies and more than 60 human trials.
Pycnogenol®’s versatility stems from its ability to boost your body’s antioxidant defenses. It inhibits the free-radical activity that can harm your cells, tissue, organs and even DNA. Pycnogenol® also supports healthy glucose metabolism and has been shown to help maintain already-healthy blood sugar levels.
Our Pycnogenol® capsules are size “1” ( approximately 0.76 inches in length and 0.27 inches in width).
Not necessarily. Pycnogenol® French Maritime Pine Bark extract is best taken in the morning and can be taken with or without food.
Although most pine bark extracts on the market are counterfeit products of China, Pycnogenol® dried French Maritime pine extract is sourced and sustainably produced in France.
No. Based on 40 years of research and over 230 scientific articles and clinical trials, it is unlikely to be a concern if Pycnogenol® were taken longer than 6 months. Toxicity test results have shown that Pycnogenol® is safe and well-tolerated, even at high doses over long periods.
Proof Vitality only offers well-researched, clinically studied ingredients in evidence-based dosages. Our patented and trademarked Pycnogenol® is a clinically validated, science-based health solution with more than 450 scientific publications. Our patented Pycnogenol® is sourced and produced exclusively France, not China.
No, Pycnogenol® does not appear to exhibit any phytoestrogen-like activities, although it has been shown to help alleviate some of the natural side effects of menopause.
It is unlikely to be a concern if combined with other products. We have not identified any known interactions between Pycnogenol® and any other dietary supplement.
We suggest discussing this decision with your health care practitioner if you take any prescription medication. However, there is no indication that Pycnogenol® would negatively interact with prescription medications based on the rigorous review of the scientific literature.
After reviewing extensive literature, we have not identified any side effects associated with taking Pycnogenol®.
References
ac-11® References
DNA Repair, Cellular Health, Anti Aging, Life Span, & Health Span
1. Sheng Y, Li L, Holmgren K, Pero RW. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001 Jul;8(4):275-82. doi: 10.1078/0944-7113-00045. PMID: 11515717.
2. Pero, R. W., Hoppe, C., & Sheng, Y. (2000). Serum Thiols as a Surrogate Estimate of DNA Repair Correlates to Mammalian Life Span. Journal of Anti-Aging Medicine. https://doi.org/10.1089/rej.1.2000.3.241
3. Banne AF, Amiri A, Pero RW. Reduced level of serum thiols in patients with a diagnosis of active disease. J Anti Aging Med. 2003;6(4):327-34. doi: 10.1089/109454503323028920. PMID: 15142434.
4. Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18. PMID: 22706308; PMCID: PMC3386805.
5. Akesson Ch, Pero RW, Ivars F. C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine. 2003 Jan;10(1):23-33. doi: 10.1078/094471103321648629. PMID: 12622460.
6. Pero RW, Amiri A, Sheng Y, Welther M, Rich M. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. Phytomedicine. 2005 Apr;12(4):255-63. doi: 10.1016/j.phymed.2004.01.008. PMID: 15898702.
7. Pero, R. W., Giampapa, V. C., & Vojdani, A. (2002). Comparison of a Broad Spectrum Anti-Aging Nutritional Supplement with and without the Addition of a DNA Repair Enhancing Cat’s Claw Extract. Journal of Anti-Aging Medicine. https://doi.org/10.1089/109454502763485467
8.Pero, R. W. (2009, September 1). In vivo treatment of humans with quinic acid enhances DNA repair and reduces the influence of lifestyle factors on risk to disease. Document – Gale Academic OneFile. https://go.gale.com/ps/i.do?id=GALE%7CA215925274&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=09732691&p=AONE&sw=w&userGroupName=anon%7E6ddd846
9. Guthrie OW. Dynamic compartmentalization of DNA repair proteins within spiral ganglion neurons in response to noise stress. Int J Neurosci. 2012 Dec;122(12):757-66. doi: 10.3109/00207454.2012.721828. Epub 2012 Oct 16. PMID: 22900489.
Immune Health, Inflammation Response, Apoptosis, & Cellular Senescence
10. Sheng Y, Pero RW, Amiri A, Bryngelsson C. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Res. 1998 Sep-Oct;18(5A):3363-8. PMID: 9858909.
11. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000 Feb;69(2):115-26. doi: 10.1016/s0378-8741(99)00070-7. PMID: 10687868.
12. Sheng Y, Pero RW, Wagner H. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000 Apr;7(2):137-43. doi: 10.1016/S0944-7113(00)80086-0. PMID: 10839217.
13. Lamm S, Sheng Y, Pero RW. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine. 2001 Jul;8(4):267-74. doi: 10.1078/0944-7113-00046. PMID: 11515716.
Brain Health, Neurological Support, Cognitive Function, Hearing
14. Guthrie OW, Gearhart CA, Fulton S, Fechter LD. Carboxy alkyl esters of Uncaria tomentosa augment recovery of sensorineural functions following noise injury. Brain Res. 2011 Aug 17;1407:97-106. doi: 10.1016/j.brainres.2011.06.044. Epub 2011 Jun 24. PMID: 21762882.
15. Guthrie, O. W., & Xu, H. (2013b). Reduced Phosphorylation of Histone Variant H2Ax in the Organ of Corti is Associated with Otoprotection from Noise Injury. Otolaryngology, 03(01). https://doi.org/10.4172/2161-119x.1000131
16. Guthrie OW. Preservation of Neural Sensitivity after Noise-Induced Suppression of Sensory Function. J Am Acad Audiol. 2016 Jan;27(1):49-61. doi: 10.3766/jaaa.15047. PMID: 26809326.
17. Shi Z, Lu Z, Zhao Y, Wang Y, Zhao-Wilson X, Guan P, Duan X, Chang YZ, Zhao B. Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model. Neurochem Int. 2013 Jun;62(7):940-7. doi: 10.1016/j.neuint.2013.03.001. Epub 2013 Mar 14. PMID: 23500604.
Safety, Efficacy, Functionality
18. Montoro P, Carbone V, Quiroz Jde D, De Simone F, Pizza C. Identification and quantification of components in extracts of Uncaria tomentosa by HPLC-ES/MS. Phytochem Anal. 2004 Jan-Feb;15(1):55-64. doi: 10.1002/pca.740. PMID: 14979528.
19. Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F. Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100. Int Immunopharmacol. 2005 Jan;5(1):219-29. doi: 10.1016/j.intimp.2004.09.028. PMID: 15589483.
20. Sheng Y, Akesson C, Holmgren K, Bryngelsson C, Giamapa V, Pero RW. An active ingredient of Cat’s Claw water extracts identification and efficacy of quinic acid. J Ethnopharmacol. 2005 Jan 15;96(3):577-84. doi: 10.1016/j.jep.2004.10.002. Epub 2004 Dec 8. PMID: 15619581.
21. Historical Development of Uncaria Preparations and Their Related bioactive Components. novapublishers.com.(Pero: Nova Sciences Publishers, Chapter 10, 2010)
22. McDonnell AM, Dang CH. Basic review of the cytochrome p450 system. J Adv Pract Oncol. 2013 Jul;4(4):263-8. doi: 10.6004/jadpro.2013.4.4.7. PMID: 25032007; PMCID: PMC4093435.
Antioxidant Potential
23. Brunswick Labs, Certificate of Analysis, ORAC Value results for ac-11®
24. Pero RW, Lund H, Leanderson T. Antioxidant metabolism induced by quinic acid. Increased urinary excretion of tryptophan and nicotinamide. Phytother Res. 2009 Mar;23(3):335-46. doi: 10.1002/ptr.2628. PMID: 18844285.
25. Pero RW, Lund H. Dietary quinic acid supplied as the nutritional supplement AIO + AC-11® leads to induction of micromolar levels of nicotinamide and tryptophan in the urine. Phytother Res. 2011 Jun;25(6):851-7. doi: 10.1002/ptr.3348. Epub 2010 Nov 22. PMID: 21104945.
Pycnogenol® References
Skin Health, Anti-Aging, Beauty From Within
1. Belcaro G, Luzzi R, Hu S, Cesarone MR, Dugall M, Ippolito E, Corsi M, Caporale S. Improvement in signs and symptoms in psoriasis patients with Pycnogenol® supplementation. Panminerva Med. 2014 Mar;56(1):41-8. PMID: 24637472.
2. Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J. Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin Pharmacol Physiol. 2012;25(2):86-92. doi: 10.1159/000335261. Epub 2012 Jan 21. PMID: 22270036.
3. Ni Z, Mu Y, Gulati O. Treatment of melasma with Pycnogenol. Phytother Res. 2002 Sep;16(6):567-71. doi: 10.1002/ptr.1085. PMID: 12237816.
4. Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, Watson RR, Packer L. Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med. 2001 Jan 15;30(2):154-60. doi: 10.1016/s0891-5849(00)00445-7. PMID: 11163532.
Brain Health & Cognitive Function, Neurological Support, Hearing
5. Trebatická J, Kopasová S, Hradecná Z, Cinovský K, Skodácek I, Suba J, Muchová J, Zitnanová I, Waczulíková I, Rohdewald P, Duracková Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur Child Adolesc Psychiatry. 2006 Sep;15(6):329-35. doi: 10.1007/s00787-006-0538-3. Epub 2006 May 13. PMID: 16699814.
6. Grossi MG, Belcaro G, Cesarone MR, Dugall M, Hosoi M, Cacchio M, Ippolito E, Bavera P. Improvement in cochlear flow with Pycnogenol® in patients with tinnitus: a pilot evaluation. Panminerva Med. 2010 Jun;52(2 Suppl 1):63-7. PMID: 20657537.
7. Belcaro G, Luzzi R, Dugall M, Ippolito E, Saggino A. Pycnogenol® improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged 35-55. J Neurosurg Sci. 2014 Dec;58(4):239-48. Epub 2014 Mar 28. PMID: 24675223.
8. Belcaro G, Dugall M, Ippolito E, Hu S, Saggino A, Feragalli B. The COFU3 Study. Improvement in cognitive function, attention, mental performance with Pycnogenol® in healthy subjects (55-70) with high oxidative stress. J Neurosurg Sci. 2015 Dec;59(4):437-46. PMID: 26635191.
9. Luzzi R, Belcaro G, Zulli C, Cesarone MR, Cornelli U, Dugall M, Hosoi M, Feragalli B. Pycnogenol® supplementation improves cognitive function, attention and mental performance in students. Panminerva Med. 2011 Sep;53(3 Suppl 1):75-82. PMID: 22108481.
10. Ryan J, Croft K, Mori T, Wesnes K, Spong J, Downey L, Kure C, Lloyd J, Stough C. An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. J Psychopharmacol. 2008 Jul;22(5):553-62. doi: 10.1177/0269881108091584. PMID: 18701642.
Cardiovascular Health: Heart, Veins, Blood Pressure, Circulation, Endothelium, Nitric Oxide
11. Arcangeli P. Pycnogenol in chronic venous insufficiency. Fitoterapia. 2000 Jun;71(3):236-44. doi: 10.1016/s0367-326x(99)00164-1. PMID: 10844161.
12. Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Ruffini I, Fano F, Hosoi M. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol. Angiology. 2005 Nov-Dec;56(6):699-705. doi: 10.1177/000331970505600607. PMID: 16327946.
13. Belcaro G, Dugall M, Luzzi R, Ippolito E, Cesarone MR. Postpartum Varicose Veins: Supplementation with Pycnogenol or Elastic Compression-A 12-Month Follow-Up. Int J Angiol. 2017 Mar;26(1):12-19. doi: 10.1055/s-0033-1363784. Epub 2014 May 29. PMID: 28255210; PMCID: PMC5330748.
14. Belcaro G. A Clinical Comparison of Pycnogenol, Antistax, and Stocking in Chronic Venous Insufficiency. Int J Angiol. 2015 Dec;24(4):268-74. doi: 10.1055/s-0035-1556060. Epub 2015 Jul 15. PMID: 26648668; PMCID: PMC4656166.
15. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Acerbi G, Cacchio M, Di Renzo A, Hosoi M, Stuard S, Corsi M. Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study. Angiology. 2006 Oct-Nov;57(5):569-76. doi: 10.1177/0003319706291392. Erratum in: Angiology. 2008 Jun-Jul;59(3):385. PMID: 17067979.
16. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Acerbi G, Cacchio M, Di Renzo A, Hosoi M, Stuard S, Corsi M. Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study. Clin Appl Thromb Hemost. 2006 Apr;12(2):205-12. doi: 10.1177/107602960601200209. PMID: 16708123.
17. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Ippolito E, Fano F, Dugall M, Cacchio M, Di Renzo A, Hosoi M, Stuard S, Corsi M. Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study. Phytomedicine. 2010 Sep;17(11):835-9. doi: 10.1016/j.phymed.2010.04.009. Epub 2010 Jun 25. PMID: 20579863.
18. Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res. 2002 Mar;16 Suppl 1:S1-5. doi: 10.1002/ptr.1010. PMID: 11933130.
19. Petrassi C, Mastromarino A, Spartera C. PYCNOGENOL in chronic venous insufficiency. Phytomedicine. 2000 Oct;7(5):383-8. doi: 10.1016/S0944-7113(00)80059-8. PMID: 11081989.
20. Riccioni C, Sarcinella R, Izzo A, Palermo G, Liguori M. Efficacia della Troxerutina associata al Pycnogenol nel trattamento farmacologico dell’insufficienza venosa [Effectiveness of Troxerutin in association with Pycnogenol in the pharmacological treatment of venous insufficiency]. Minerva Cardioangiol. 2004 Feb;52(1):43-8. Italian. PMID: 14765037.
21. Schmidtke I, Schoop W. Pycnogenol—stasis edema and its medical treatment [in German]. Z Ganzheits Med. 1995;3:114-115.
22. Belcaro G, Cesarone MR, Rohdewald P, Ricci A, Ippolito E, Dugall M, Griffin M, Ruffini I, Acerbi G, Vinciguerra MG, Bavera P, Di Renzo A, Errichi BM, Cerritelli F. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost. 2004 Oct;10(4):373-7. doi: 10.1177/107602960401000410. PMID: 15497024.
23. Errichi BM, Belcaro G, Hosoi M, Cesarone MR, Dugall M, Feragalli B, Bavera P, Hosoi M, Zulli C, Corsi M, Ledda A, Luzzi R, Ricci A. Prevention of post thrombotic syndrome with Pycnogenol® in a twelve month study. Panminerva Med. 2011 Sep;53(3 Suppl 1):21-7. PMID: 22108473.
24. Rodriguez P, Belcaro G, Dugall M, Hu S, Luzzi R, Ledda A, Ippolito E, Corsi M, Ricci A, Feragalli B, Cornelli U, Gizzi C, Hosoi M. Recurrence of retinal vein thrombosis with Pycnogenol® or Aspirin® supplementation: a registry study. Panminerva Med. 2015 Sep;57(3):121-5. PMID: 25971329.
25. Belcaro G, Cesarone MR, Ricci A, Cornelli U, Rodhewald P, Ledda A, Di Renzo A, Stuard S, Cacchio M, Vinciguerra G, Gizzi G, Pellegrini L, Dugall M, Fano F. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol. Clin Appl Thromb Hemost. 2006 Oct;12(4):440-4. doi: 10.1177/1076029606292248. PMID: 17000888.
26. Cesarone MR, Belcaro G, Stuard S, Schönlau F, Di Renzo A, Grossi MG, Dugall M, Cornelli U, Cacchio M, Gizzi G, Pellegrini L. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants–a controlled study. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):41-6. doi: 10.1177/1074248409356063. Epub 2010 Jan 22. PMID: 20097689.
27. A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patients. (n.d.). University of Arizona. https://experts.arizona.edu/en/publications/a-randomized-double-blind-placebo-controlled-prospective-16-week-/fingerprints/
28. Liu X, Wei J, Tan F, Zhou S, Würthwein G, Rohdewald P. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004 Jan 2;74(7):855-62. doi: 10.1016/j.lfs.2003.07.037. PMID: 14659974.
29. Stuard S, Belcaro G, Cesarone MR, Ricci A, Dugall M, Cornelli U, Gizzi G, Pellegrini L, Rohdewald PJ. Kidney function in metabolic syndrome may be improved with Pycnogenol®. Panminerva Med. 2010 Jun;52(2 Suppl 1):27-32. PMID: 20657531.
30. Hu S, Belcaro G, Cornelli U, Luzzi R, Cesarone M, Dugall M, Feragalli B, Errichi B, Ippolito E, Grossi M, Hosoi M, Gizzi G, Trignani M. Effects of Pycnogenol® on endothelial dysfunction in borderline hypertensive, hyperlipidemic, and hyperglycemic individuals: the borderline study. Int Angiol. 2015 Feb;34(1):43-52. Epub 2014 Nov 13. PMID: 25391252.
31.) Belcaro G, Cornelli U, Luzzi R, Cesarone MR, Dugall M, Feragalli B, Errichi S, Ippolito E, Grossi MG, Hosoi M, Cornelli M, Gizzi G. Pycnogenol® supplementation improves health risk factors in subjects with metabolic syndrome. Phytother Res. 2013 Oct;27(10):1572-8. doi: 10.1002/ptr.4883. Epub 2013 Jan 28. PMID: 23359520.
Inflammation Response, Immune Function, Respiratory Health, Lung Function, Allergy & Sinus
32. Belcaro G, Luzzi R, Cesinaro Di Rocco P, Cesarone MR, Dugall M, Feragalli B, Errichi BM, Ippolito E, Grossi MG, Hosoi M, Errichi S, Cornelli U, Ledda A, Gizzi G. Pycnogenol® improvements in asthma management. Panminerva Med. 2011 Sep;53(3 Suppl 1):57-64. PMID: 22108478.
33. Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR. Pycnogenol((R)) in the Management of Asthma. J Med Food. 2001 Winter;4(4):201-209. doi: 10.1089/10966200152744472. PMID: 12639402.
34. Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 2004;41(8):825-32. doi: 10.1081/jas-200038433. PMID: 15641632.
35. Wilson D, Evans M, Guthrie N, Sharma P, Baisley J, Schonlau F, Burki C. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 2010 Aug;24(8):1115-9. doi: 10.1002/ptr.3232. PMID: 20549654.
36. Otorinolaringologia 2013 September;63(3):151-61. (n.d.). https://www.minervamedica.it/en/journals/Otorhinolaryngology/article.php?cod=R27Y2013N03A0151
37. Belcaro G, Cesarone MR, Genovesi D, Ledda A, Vinciguerra G, Ricci A, Pellegrini L, Gizzi G, Ippolito E, Dugall M, Cacchio M, Di Renzo A, Stuard S. Pycnogenol may alleviate adverse effects in oncologic treatment. Panminerva Med. 2008 Sep;50(3):227-34. PMID: 18927527.
Blood Sugar, Glucose Metabolism, & Kidney Function
38. Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Gizzi G, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M. Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol. Clin Appl Thromb Hemost. 2006 Jul;12(3):318-23. doi: 10.1177/1076029606290133. PMID: 16959685.
39. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Cipollone G, Acerbi G, Cacchio M, Del Boccio G, Di Renzo A, Stuard S, Corsi M. Improvement of diabetic microangiopathy with pycnogenol: A prospective, controlled study. Angiology. 2006 Aug-Sep;57(4):431-6. doi: 10.1177/0003319706290318. PMID: 17022378.
40. Liu X, Wei J, Tan F, Zhou S, Würthwein G, Rohdewald P. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci. 2004 Oct 8;75(21):2505-13. doi: 10.1016/j.lfs.2003.10.043. PMID: 15363656.
41. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care. 2004 Mar;27(3):839. doi: 10.2337/diacare.27.3.839. PMID: 14988316.
42. Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008 May;28(5):315-20. doi: 10.1016/j.nutres.2008.03.003. PMID: 19083426.
Joint Health
43. Belcaro G, Cesarone MR, Errichi S, Zulli C, Errichi BM, Vinciguerra G, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Errichi S, Gizzi G, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M, Rohdewald P. Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspects. Phytother Res. 2008 Apr;22(4):518-23. doi: 10.1002/ptr.2376. PMID: 18386255.
44. Cisár P, Jány R, Waczulíková I, Sumegová K, Muchová J, Vojtassák J, Duraćková Z, Lisý M, Rohdewald P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother Res. 2008 Aug;22(8):1087-92. doi: 10.1002/ptr.2461. PMID: 18570266.
45. A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patients. (n.d.). University of Arizona. https://experts.arizona.edu/en/publications/a-randomized-double-blind-placebo-controlled-prospective-16-week-/fingerprints/
Eye Health
46. Spadea L, Balestrazzi E. Treatment of vascular retinopathies with Pycnogenol. Phytother Res. 2001 May;15(3):219-23. doi: 10.1002/ptr.853. PMID: 11351356.
Active Lifestyle & Sports Performance
47. Vinciguerra G, Belcaro G, Cesarone MR, Rohdewald P, Stuard S, Ricci A, Di Renzo A, Hosoi M, Dugall M, Ledda A, Cacchio M, Acerbi G, Fano F. Cramps and muscular pain: prevention with pycnogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy. Angiology. 2006 May-Jun;57(3):331-9. doi: 10.1177/000331970605700309. PMID: 16703193.
Oral Care
48. Kimbrough C, Chun M, dela Roca G, Lau BH. PYCNOGENOL chew-ing gum minimizes gingival bleeding and plaque formation. Phytomedicine. 2002;9(5):410-413.
Men’s Health
49. D̆Uračková, Z. (2003). Lipid metabolism and erectile function improvement by pycnogenol®, extract from the bark of pinus pinaster in patients suffering from erectile dysfunction-a pilot study. AGRIS: International Information System for the Agricultural Science and Technology. https://agris.fao.org/agris-search/search.do?recordID=US201600076652
Women’s Health
50. Errichi S, Bottari A, Belcaro G, Cesarone MR, Hosoi M, Cornelli U, Dugall M, Ledda A, Feragalli B. Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition. Panminerva Med. 2011 Sep;53(3 Suppl 1):65-70. PMID: 22108479.
51. Kohama T, Negami M. Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial. J Reprod Med. 2013 Jan-Feb;58(1-2):39-46. PMID: 23447917.
52. Maia H Jr, Haddad C, Casoy J. Combining oral contraceptives with a natural nuclear factor-kappa B inhibitor for the treatment of endometriosis-related pain. Int J Womens Health. 2013 Dec 21;6:35-9. doi: 10.2147/IJWH.S55210. PMID: 24379702; PMCID: PMC3873204.
53. Maia H Jr, Haddad C, Casoy J. The effect of pycnogenol on patients with dysmenorrhea using low-dose oral contraceptives. Int J Womens Health. 2014 Dec 11;6:1019-22. doi: 10.2147/IJWH.S75389. PMID: 25525393; PMCID: PMC4266261.
54. Yang HM, Liao MF, Zhu SY, Liao MN, Rohdewald P. A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women. Acta Obstet Gynecol Scand. 2007;86(8):978-85. doi: 10.1080/00016340701446108. PMID: 17653885.
55. Kohama T, Suzuki N, Ohno S, Inoue M. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea: an open clinical trial. J Reprod Med. 2004 Oct;49(10):828-32. PMID: 15568408.
56. Suzuki N, Uebaba K, Kohama T, Moniwa N, Kanayama N, Koike K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study. J Reprod Med. 2008 May;53(5):338-46. PMID: 18567279.
57. Kohama T, Herai K, Inoue M. Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate. J Reprod Med. 2007 Aug;52(8):703-8. PMID: 17879831.
58. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res. 2006 Mar;20(3):232-4. doi: 10.1002/ptr.1840. PMID: 16521117.
Hemorrhoid Support
59. Belcaro G, Gizzi G, Pellegrini L, Dugall M, Luzzi R, Corsi M, Ippolito E, Ricci A, Cesarone MR, Ledda A, Bottari A, Errichi BM. Pycnogenol® in postpartum symptomatic hemorrhoids. Minerva Ginecol. 2014 Feb;66(1):77-84. PMID: 24569406.
Edema on Long Flights
60. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ippolito E, Scoccianti M, Ricci A, Dugall M, Cacchio M, Ruffini I, Fano F, Acerbi G, Vinciguerra MG, Bavera P, Di Renzo A, Errichi BM, Mucci F. Prevention of edema in long flights with Pycnogenol. Clin Appl Thromb Hemost. 2005 Jul;11(3):289-94. doi: 10.1177/107602960501100307. PMID: 16015414.