Anti Aging Mega Bundle

Optimize Hormones, Combat Accelerated Aging and Restore Sexual Function with Versatile, Patented Ingredients You Can Trust (LJ100®, ac-11®, AstaReal®, and Pycnogenol®).

Benefits at a Glance

• Sexual Health: Enhances sexual function, arousal, and alpha-pheromones.
• Optimize Hormones: Balances testosterone, DHEA, and cortisol levels to supercharge vitality.
• Rejuvenate DNA: Enhances the body’s natural ability to repair its DNA and maintain telomere length.
• Youthful Skin: Boosts collagen and elastin synthesis, hyaluronic acid and hydration, and elasticity, while reducing skin fatigue and pigmentation. Also, limits photo-aging, reduces the size of wrinkles, and improves skin microtexture.
• Brain Health: Improves memory, enhances cognitive function, and reduces test anxiety. Also, repairs and protects neural function damaged by overexposure to high-decibel noise.
• Immune Boosting Power: Increases the life cycle of white blood cells and promotes healthy immune function.
• Heart Health: Supports healthy circulatory and endothelial function and boosts nitric oxide levels.
• Athletic Performance: Enhances mental and physical energy, muscle performance, and endurance.
• Weight Management: Supports lean muscle mass and prevents binge eating.

What is the Anti-Aging Mega Bundle, and what remarkable advantages do its four key ingredients provide?

The Anti-Aging Mega Bundle unites LJ100®, ac-11®, AstaReal, and Pycnogenol – ingredients backed by extensive clinical research and a cumulative total of 390 clinical studies. This bundle doesn’t merely deliver health benefits; it deliver more than 25 proven benefits to invigorate your sexual vitality, harmonize hormones, amplify mental and physical performance, and effectively counteract accelerated aging.

LJ100® – the ultimate catalyst for sexual health and function – taps into your primal potential, igniting a resurgence of passion. By harmonizing testosterone and DHEA levels, it not only amplifies your prowess in the bedroom but also revitalizes your overall energy and strength. With LJ100®, your most fundamental desires become the driving force, propelling you to conquer each day with unyielding vigor.

Ac-11® supports your body’s innate restorative mechanisms, facilitating DNA repair and telomere elongation for optimal cellular vitality. It further enhances skin elasticity through augmented type-III collagen production during sun exposure.

AstaReal® Astaxanthin emerges as nature’s unparalleled guardian against free radicals, boasting a singlet oxygen quenching capacity 6000 times greater than that of vitamin C. This potent antioxidant fortifies cell membranes, mitochondria, skin, muscles, brain, and eyes, utilizing its distinctive structure for comprehensive coverage that outperforms vitamin C by 6000 times against singlet oxygen.

Pycnogenol® French maritime pine bark extract offers a distinctive blend of bioflavonoids that masterfully regulate inflammation and neutralize free radicals. This super nutrient propels blood circulation, thereby enhancing heart health, cognitive function, and immune resilience. Moreover, it binds with collagen and elastin, renews hyaluronic acid synthesis, and

The Anti-Aging Mega Bundle comprises four exceptional ingredients: LJ100®, ac-11®, AstaReal®, and Pycnogenol®. These ingredients boast an extensive history of clinical research, collectively participating in over 390 clinical studies.

Our supplements provide precise, science-based dosages aligned with clinical data for optimal potency. Our LJ100® offers a potent 200 mg daily, ac-11® delivers a robust 700 mg per capsule, AstaReal® conveniently offers the maximum dose of 12 mg per softgel, and Pycnogenol® contributes 100 mg per capsule.

Taken daily, these four potent supplements yield over 25 science based health benefits, combating accelerated aging, enhancing performance both at work and in the bedroom, fostering lean muscle growth, facilitating weight management, and nurturing inner beauty for both women and men. Experience the power of ingredients that surpass 99.99% of the generic, filler-laden counterfeits on the market.

Balance Free Testosterone

Supercharge your energy, sleep quality, lean mass, mood balance, and libido with increased free testosterone levels, benefiting both men and women. Age-related decline in free testosterone leads to reduced vitality, muscle loss, and belly fat. LJ100®, substantiated by a notable study with male participants, showcased its potential to enhance health markers significantly. Notably, across various domains, including sexual health, scores improved remarkably. The study yielded a striking 73% increase in free testosterone levels, alongside a 47% surge in DHEA and a 30% drop in SHBG levels.

Ignite Sexual Health

Elevate your intimate life with LJ100® – a potent alternative to prescription medications, delivering a remarkable 62% increase in sexual desire scores, heightened satisfaction, and improved libido. LJ100® goes beyond by influencing sexual communication through pheromones, potentially intensifying attraction and desire. Its cGMP level effects mirror those of prescription drugs, offering enhanced erectile function without drawbacks. Uplift your sexual well-being with LJ100® Tongkat Ali from Proof Vitality.

Boost Physical and Mental Energy

Amplify your athletic prowess and endurance with LJ100®, promoting muscle building through increased free testosterone and inhibiting muscle breakdown due to cortisol rise. LJ100® drives an anabolic state, resulting in enhanced performance, muscle strength, size, and fat-free mass. This supplement stimulates endogenous testosterone production, with one study revealing up to 132.63% increase within just 10 days. Elevate your fitness journey with LJ100® Tongkat Ali from Proof Vitality.

Aid Weight Management

Elevate mood, energy, and weight management through cortisol and testosterone balance. LJ100®’s impact was demonstrated in a six-week program, showing body weight and body fat reduction, decreased cortisol/testosterone ratio, improved cholesterol levels, and mood enhancement. Elevate your weight management journey with LJ100® Tongkat Ali from Proof Vitality.

Enhance Mood and Further Contribute to Weight Management

Experience mood upliftment and weight management with LJ100®. Daily LJ100® supplementation led to significant reductions in tension, anger, and confusion, coupled with improved stress hormone profiles and weight management. The results suggest LJ100®’s potential to restore hormonal balance and uplift mood in response to stressors. Elevate your mood and weight management journey with LJ100® Tongkat Ali from Proof Vitality.

Support Adrendal Health, Fostering a Healthy Stress Response & Energy

Boost Elevate your stress response naturally with LJ100®. Controlled studies demonstrated enhanced quality of life, mood, and stress levels in moderately stressed participants, coupled with improvements in mental clarity, emotional well-being, vigor, and testosterone levels. Experience reductions in physical and cognitive stress, along with positive effects on immune markers. Elevate your stress response naturally with LJ100® Tongkat Ali from Proof Vitality.

Offset the Effects of Andropause

Combat Andropause with LJ100®, counteracting declining testosterone production that causes fatigue, reduced muscle strength, mood changes, and more. Studies reveal up to 132.63% increase in testosterone levels within 10 days and improved symptoms in late-onset hypogonadism, enhancing physical, psychological, and sexual aspects. Upgrade your vitality with LJ100® Tongkat Ali from Proof Vitality.

Promote Healthy Bone Remodeling

Support lifelong bone remodeling with LJ100®, maintaining the balance between bone resorption and new bone formation for optimal bone health. LJ100® improves bone structure, osteoblast-to-osteoclast ratio, serum testosterone levels, and osteoblast cell activity. It also inhibits osteoclast activity, contributing to enhanced bone density. Elevate your bone health naturally with LJ100® Tongkat Ali from Proof Vitality.

Longevity & Health Span

Our Anti Aging Beauty Bundle goes beyond being a mere advanced solution for skin care. We selected ac-11® not only for its role in assisting your body’s DNA repair but also for its capacity to enhance cellular health through the promotion of apoptosis (the removal of damaged cells). As we age, the accumulation of damaged cells (senescent cells) becomes a key factor in hastening aging and contributing to diseases. AstaReal® and Pycnogenol® work in synergy to counteract free radicals and enhance blood flow, enabling you to experience optimal well-being.

Antioxidant & Blood Sugar

Pycnogenol® showcases its prowess in maintaining already-healthy glucose levels. Moreover, it reinforces the body’s armor of antioxidant defenses with potent phytonutrient compounds that counteract free-radical activity – the culprit behind potential harm to cells, tissues, organs, and DNA. AstaReal® Astaxanthin emerges as a powerhouse free radical scavenger from nature, boasting a potency 6000 times that of vitamin C. In the mix, LJ100® steps in, potentially boosting insulin secretion and facilitating glucose uptake within muscle and adipose cells, thereby orchestrating optimal glucose control. The heightened glucose absorption in muscle cells could also translate to elevated energy levels and enhanced physical performance.

Brain & Cognitive Function

AstaReal® and Pycnogenol® offer diverse positive physiological effects on the brain. Randomized double-blind, placebo-controlled studies confirm that 3 months of supplementation with our patented natural astaxanthin extract (12mg/daily) heightens blood flow, memory, mental agility, multitasking, and accelerated learning in seniors. Research also highlights Pycnogenol® French maritime pine bark extract’s capacity to enhance cognitive function, specifically improving numerical and spatial working memory. This extract has been shown to ameliorate memory and test scores among college students, enhancing mental performance while reducing test anxiety by 17%. Enhance memory, alertness, multitasking, and age-related forgetfulness. Reduce oxidation of red blood cells, nurturing brain health. Promote amplified capillary blood flow and heightened blood antioxidant quality.

Collagen, Hair, Nails, & Skin

The skin, the body’s largest and most intricate organ, consists of numerous layers, each performing distinct and crucial functions. In this context, ac-11®, AstaReal®, and Pycnogenol® offer unmatched and proven advantages for your skin. Research indicates that ac-11® notably amplifies the natural production of type-III collagen in cutaneous tissue, particularly during sun exposure—type 3 collagen being responsible for the youthful suppleness and elasticity of skin. AstaReal® natural astaxanthin actively enhances the vitality and luminosity of your skin by providing robust protection and support to all layers. Pycnogenol® exhibits the capability to invigorate collagen synthesis and augment skin elasticity while mitigating skin fatigue. Moreover, Pycnogenol® showcases its effectiveness by boosting hyaluronic acid production, effectively moisturizing the skin. It also hinders the degradation of collagen and elastin, thus curbing photo-aging effects and safeguarding your skin, ultimately leading to a more vibrant and uniform complexion.

DNA Repair & Telomere Health

ac-11® plays a crucial role in supporting DNA repair. Maintaining the health of our cells, specifically addressing the daily damage to our DNA, is widely recognized as a pivotal factor in counteracting accelerated aging.

Numerous environmental factors, ranging from pollution and ultraviolet radiation from the sun to electromagnetic radiation emitted by smart devices, along with contaminated water, GMOs, and processed foods, contribute to cellular and DNA damage. Notably, serious diseases like cancer are closely linked to cellular and DNA damage resulting from these factors.

In this intricate defense mechanism, our cells rely on antioxidants to shield our DNA from harm. The body employs a natural process called apoptosis to repair or eliminate damaged cells. However, when cellular DNA damage surpasses the body’s repair capacity, it leads to an escalation of physical signs of aging and a decline in quality of life. Studies indicate that a dosage of up to 700 mg of ac-11® daily could significantly assist the body in defending against the natural aging process.

Digestion & GI Health

Gut health serves as the cornerstone of overall well-being, with the digestive system being one of the body’s most delicate organs. Through clinical research, it has been demonstrated that incorporating AstaReal® natural astaxanthin into your regimen can play a pivotal role in promoting optimal gastric health. This is achieved by assisting your body in alleviating gastrointestinal discomfort, providing protection against stomach ulcers, and fostering equilibrium within the gut’s intricate microbiome.

Hearing & Vision Health

Concerned about the effects of loud music and high-decibel noise? Our solution, ac-11®, aids in repairing neural damage from overexposure to such noise.

Clinical studies show AstaReal® astaxanthin eases Computer Vision Syndrome discomfort – blurred vision, eye fatigue, and irritation. It also reduces eye fatigue by countering inflammation from prolonged visual stress and ciliary muscle tension.

Pycnogenol® improves eye health by scavenging free radicals. It surpasses vitamins C & E, CoQ10, and grape seed extract in shielding retinal lipids. Studies reveal Pycnogenol® strengthens retinal capillaries, enhancing endothelial function for retinal microvessel circulation.

Heart, Veins & Circulation

Experience Natural Cardiovascular Support with AstaReal® and Pycnogenol®

A growing body of clinical research substantiates the effectiveness of AstaReal® natural astaxanthin in promoting cardiovascular well-being. Scientific studies have revealed that our patented astaxanthin plays a vital role in reducing oxidative stress and inflammation, enhancing capillary blood flow, and improving lipid profiles.

Pycnogenol® contributes to the maintenance of healthy endothelial and arterial functions by effectively inhibiting inflammatory agents known as cytokines. Moreover, it actively supports the maintenance of optimal nitric oxide levels within the arteries, a crucial factor in preserving endothelial functionality and ensuring efficient arterial blood flow. This dual action not only fosters a balanced inflammatory response but also facilitates healthy platelet function.

Immune Support

Multiple studies have demonstrated that a daily intake of 700 mg ac-11® can potentially elevate your white blood cell count, thereby enhancing your immune response to counter infections and viruses. Furthermore, other research indicates that it facilitates a balanced response to inflammation, thereby regulating your immune function and preventing potential overreactions.

Similar to the other systems within your body, your immune system operates more effectively when fortified. AstaReal® plays a significant role in harmonizing and reinforcing the immune system, thereby enhancing its capacity to safeguard the body against diseases and illnesses. Additionally, it curbs excessive immune reactions that could lead to undesirable inflammation.

Scientific investigations have established that Pycnogenol® aids your body in combating inflammation and normalizing immune responses by suppressing the activity of nuclear factor-kappa B (NF-ĸB)—an immune cell responsible for triggering inflammation.

Inflammation Response

Research underscores that ac-11® potentially aids in maintaining balanced expression of the NF-kB factor within cells, thereby fostering a favorable inflammatory response. This orchestrated regulation of the NF-kB factor contributes to apoptosis – the programmed cellular demise that facilitates the removal of damaged cells and encourages the propagation of healthy ones.

Pycnogenol®, on the other hand, comprises a range of phenolic compounds, including ferulic acid, caffeic acid, catechin, and taxifolin. These compounds exhibit remarkable capabilities in neutralizing free radicals and fostering a robust response to inflammation.

Joint, Mobility & Bone Health

Support lifelong bone remodeling with LJ100®, maintaining the balance between bone resorption and new bone formation for optimal bone health. LJ100® improves bone structure, osteoblast-to-osteoclast ratio, serum testosterone levels, and osteoblast cell activity. It also inhibits osteoclast activity, contributing to enhanced bone density. Elevate your bone health naturally with LJ100® Tongkat Ali from Proof Vitality.

Furthermore, sustaining optimal joint health holds immense significance as it facilitates unrestricted and comfortable movement, ultimately enhancing overall life quality. Renowned for its remarkable properties, Pycnogenol® French maritime pine bark extract contributes to the promotion of joint flexibility and mobility. Additionally, it offers a natural alleviation of joint discomfort by actively suppressing inflammation and diminishing inflammatory markers. Embracing Pycnogenol® can lead to decreased pain and a potential reduction in medication dependence for individuals grappling with arthritic joint conditions, ultimately enhancing their joint functionality.

Men’s Health

Research has shown that supplementation with Pycnogenol® significantly improves erectile function by 45 percent. The resulting arterial relaxation supports healthy erectile function by helping fill the corpus cavernosum with blood.

A study comprising 75 healthy men suggests that supplementation with Pycnogenol® may help counteract benign prostate enlargement and help facilitate emptying of the bladder after 60 days of supplementation.

Although both men and women can enjoy a cornucopia of science-based health benefits, LJ100 easily sets the bar when it comes to all-around men's health. Here are the 15 science-based Benefits of LJ100®:

• Elevates Sexual Function and Libido
• Maintains High Free Testosterone Levels
• Inhibits Sex Hormone Binding Globulin
• Reduces Cortisol, the Stress Hormone
• Enhances Mood Profiles
• Curbs Binge Eating for Successful Weight Loss
• Fosters an Anabolic State while Reducing Catabolism
• Decreases Fatigue and Tension
• Amplifies Endurance and Stamina for Athletes
• Offers Natural Alternatives to Testosterone Replacement Therapy
• Nurtures Overall Well-being and Hormonal Health
• Supports Healthy Blood Sugar Levels
• Encourages Healthy Bone Turnover
• Bolsters Immune Function
• Manages a Healthy Inflammatory Response

Collectively, 28 clinical studies underscore LJ100’s potential to address a spectrum of men’s health concerns through its impactful effects on testosterone levels, fatigue reduction, muscle strength, sexual health, and overall quality of life.

Oral Care & Gum Health

Pycnogenol®, an extensively studied standardized French maritime pine bark extract, has garnered attention for its remarkable oral and dental health advantages. This potent antioxidant finds application in a diverse range of global commercial products, showcasing multifaceted contributions to oral health.

Respiratory, Allergy & Sinus

The potential of Pycnogenol® French maritime pine bark extract in addressing respiratory symptoms lies in its ability to diminish inflammation, curtail histamine release, and facilitate smoother breathing.

Sports & Active Lifestyle

Enhancing fitness and athletic performance becomes progressively demanding as age advances, necessitating greater dedication to muscle maintenance and endurance. Amid the limitations of popular supplements like protein powders and fat burners in addressing this challenge, LJ100® emerges as a potent solution with remarkable outcomes. Clinical studies on humans underscore LJ100®’s dual capability: it promotes an anabolic state, spurring muscle growth through heightened free testosterone levels, while simultaneously inhibiting a catabolic state driven by cortisol elevation, thus mitigating muscle breakdown. This dynamic equilibrium translates to amplified performance. Beyond this, LJ100® supplementation translates into elevated fat-free mass, diminished body fat, and increased muscle strength and size. These benefits trace back to LJ100®’s ability to stimulate innate testosterone production, as validated by a study demonstrating a staggering up to 132.63% increase in testosterone levels within a mere 10 days.

Simultaneously, peer-reviewed research underscores Pycnogenol® French maritime pine bark extract’s potential in counteracting age-related muscle decline. This encompasses safeguarding muscles from exertion-related harm, heightening performance and endurance, expediting recovery, and facilitating a prompt return to action. Additionally, peer-reviewed research accentuates Pycnogenol® French maritime pine bark extract’s potential to counter the muscle loss accompanying aging. This extract actively bolsters muscles through the natural aging process, enhancing both muscular function and endurance.

Furthermore, AstaReal® astaxanthin heralds a substantial advancement, profoundly augmenting muscle endurance by enhancing muscle function and elevating aerobic power. This patented astaxanthin serves as a dual agent—neutralizing free radicals and enhancing the body’s response to inflammation. Studies validate AstaReal®’s efficacy in reducing lactic acid accumulation and mitigating fatigue.

Incorporating these cutting-edge solutions into your fitness journey promises to revolutionize your athletic pursuits and amplify your active lifestyle.

Women’s Health

Scientific investigation has highlighted that Pycnogenol® significantly diminishes abdominal discomfort and cramping by 80 percent, while also reducing cramping by 77 percent, in women facing challenging menstrual periods. In addition, Pycnogenol® supplementation has demonstrated the ability to alleviate tenderness during menstruation within the span of just one month, with further relief reported after the second month.

Moreover, extensive studies underscore that Pycnogenol® naturally mitigates common symptoms like hot flashes, depression, and panic attacks that often accompany the transition into menopause, thereby offering comprehensive support during this phase.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

ac-11® References

DNA Repair, Cellular Health, Anti Aging, Life Span, & Health Span

1. Sheng Y, Li L, Holmgren K, Pero RW. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001 Jul;8(4):275-82. doi: 10.1078/0944-7113-00045. PMID: 11515717.

2. Pero, R. W., Hoppe, C., & Sheng, Y. (2000). Serum Thiols as a Surrogate Estimate of DNA Repair Correlates to Mammalian Life Span. Journal of Anti-Aging Medicine. https://doi.org/10.1089/rej.1.2000.3.241

3. Banne AF, Amiri A, Pero RW. Reduced level of serum thiols in patients with a diagnosis of active disease. J Anti Aging Med. 2003;6(4):327-34. doi: 10.1089/109454503323028920. PMID: 15142434.

4. Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18. PMID: 22706308; PMCID: PMC3386805.

5. Akesson Ch, Pero RW, Ivars F. C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine. 2003 Jan;10(1):23-33. doi: 10.1078/094471103321648629. PMID: 12622460.

6. Pero RW, Amiri A, Sheng Y, Welther M, Rich M. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. Phytomedicine. 2005 Apr;12(4):255-63. doi: 10.1016/j.phymed.2004.01.008. PMID: 15898702.

7. Pero, R. W., Giampapa, V. C., & Vojdani, A. (2002). Comparison of a Broad Spectrum Anti-Aging Nutritional Supplement with and without the Addition of a DNA Repair Enhancing Cat’s Claw Extract. Journal of Anti-Aging Medicine. https://doi.org/10.1089/109454502763485467

8.Pero, R. W. (2009, September 1). In vivo treatment of humans with quinic acid enhances DNA repair and reduces the influence of lifestyle factors on risk to disease. Document – Gale Academic OneFile. https://go.gale.com/ps/i.do?id=GALE%7CA215925274&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=09732691&p=AONE&sw=w&userGroupName=anon%7E6ddd846

9. Guthrie OW. Dynamic compartmentalization of DNA repair proteins within spiral ganglion neurons in response to noise stress. Int J Neurosci. 2012 Dec;122(12):757-66. doi: 10.3109/00207454.2012.721828. Epub 2012 Oct 16. PMID: 22900489.

Immune Health, Inflammation Response, Apoptosis, & Cellular Senescence

10. Sheng Y, Pero RW, Amiri A, Bryngelsson C. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Res. 1998 Sep-Oct;18(5A):3363-8. PMID: 9858909.

11. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000 Feb;69(2):115-26. doi: 10.1016/s0378-8741(99)00070-7. PMID: 10687868.

12. Sheng Y, Pero RW, Wagner H. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000 Apr;7(2):137-43. doi: 10.1016/S0944-7113(00)80086-0. PMID: 10839217.

13. Lamm S, Sheng Y, Pero RW. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine. 2001 Jul;8(4):267-74. doi: 10.1078/0944-7113-00046. PMID: 11515716.

Brain Health, Neurological Support, Cognitive Function, Hearing

14. Guthrie OW, Gearhart CA, Fulton S, Fechter LD. Carboxy alkyl esters of Uncaria tomentosa augment recovery of sensorineural functions following noise injury. Brain Res. 2011 Aug 17;1407:97-106. doi: 10.1016/j.brainres.2011.06.044. Epub 2011 Jun 24. PMID: 21762882.

15. Guthrie, O. W., & Xu, H. (2013b). Reduced Phosphorylation of Histone Variant H2Ax in the Organ of Corti is Associated with Otoprotection from Noise Injury. Otolaryngology, 03(01). https://doi.org/10.4172/2161-119x.1000131

16. Guthrie OW. Preservation of Neural Sensitivity after Noise-Induced Suppression of Sensory Function. J Am Acad Audiol. 2016 Jan;27(1):49-61. doi: 10.3766/jaaa.15047. PMID: 26809326.

17. Shi Z, Lu Z, Zhao Y, Wang Y, Zhao-Wilson X, Guan P, Duan X, Chang YZ, Zhao B. Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model. Neurochem Int. 2013 Jun;62(7):940-7. doi: 10.1016/j.neuint.2013.03.001. Epub 2013 Mar 14. PMID: 23500604.

Safety, Efficacy, Functionality

18. Montoro P, Carbone V, Quiroz Jde D, De Simone F, Pizza C. Identification and quantification of components in extracts of Uncaria tomentosa by HPLC-ES/MS. Phytochem Anal. 2004 Jan-Feb;15(1):55-64. doi: 10.1002/pca.740. PMID: 14979528.

19. Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F. Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100. Int Immunopharmacol. 2005 Jan;5(1):219-29. doi: 10.1016/j.intimp.2004.09.028. PMID: 15589483.

20. Sheng Y, Akesson C, Holmgren K, Bryngelsson C, Giamapa V, Pero RW. An active ingredient of Cat’s Claw water extracts identification and efficacy of quinic acid. J Ethnopharmacol. 2005 Jan 15;96(3):577-84. doi: 10.1016/j.jep.2004.10.002. Epub 2004 Dec 8. PMID: 15619581.

21. Historical Development of Uncaria Preparations and Their Related bioactive Components. novapublishers.com.(Pero: Nova Sciences Publishers, Chapter 10, 2010)

22. McDonnell AM, Dang CH. Basic review of the cytochrome p450 system. J Adv Pract Oncol. 2013 Jul;4(4):263-8. doi: 10.6004/jadpro.2013.4.4.7. PMID: 25032007; PMCID: PMC4093435.

Antioxidant Potential

23. Brunswick Labs, Certificate of Analysis, ORAC Value results for ac-11®

24. Pero RW, Lund H, Leanderson T. Antioxidant metabolism induced by quinic acid. Increased urinary excretion of tryptophan and nicotinamide. Phytother Res. 2009 Mar;23(3):335-46. doi: 10.1002/ptr.2628. PMID: 18844285.

25. Pero RW, Lund H. Dietary quinic acid supplied as the nutritional supplement AIO + AC-11® leads to induction of micromolar levels of nicotinamide and tryptophan in the urine. Phytother Res. 2011 Jun;25(6):851-7. doi: 10.1002/ptr.3348. Epub 2010 Nov 22. PMID: 21104945.

LJ100®References

1. Tambi and Saad, “Water-soluble extract of Eurycoma Longifolia Jack as a Potential Natural Energizer for Healthy Aging Men,” First Asian Andrology Forum in Shanghai China 2002, Asian Society of Sexology Conference in Singapore, December 2002.

2. “LJ100, a Potent Adaptogen, Maintains Healthy Aging in Men,” Int. J. Androl. 28 (s1), 25-44 (2005).

3. Asian J. Androl. 0154 (448) (October 2006).

4. Faculty Abstract 11, The Aging Male 10 (2), 92 (2007).

5. “LJ100® as a Potential Natural Energizer for Healthy Aging in Men,” First Asian Andrology Forum in Shanghai China, 2002.

6. S.B. Ismail et al., “Randomized Clinical Trial on the Use of LJ100 for the Improvement of Quality of Life and Sexual Well-Being in Men,” Evid. Based Complement. Alternat. Med. 2012, 429268 (2012).

7. J.K. Udani et al., “Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study,” Evidence-Based Complement. Alternat. Med. 179529 (2014).

8. M. Ismail and M. Kamarul Imran, “Eurycoma longifolia Jack in Managing Idiopathic Male Infertility,” Asian J. Androl., 12 (3) 376–380 (2010).

9. MIT research papers, 2005, in support of US Patent 7,132,117.

10. University of Malaysia, abstract from research papers, 2008.

11. University of Malaysia, abstract from research papers, circa 2008.

12. S. Hamzah and A. Yusuf, “The Ergogenic Effects of LJ100,” British Journal of Sports Medicine 2003. BASEM Abstract 37: 465-466.

13. J. Talbott et al., “Effect of [LJ 100] Eurycoma longifolia Extract on Anabolic Balance During Endurance Exercise,” Journal of the International Society of Sport Medicine 3 (1): S32 (2006).

14. “Effects of Strength Training and LJ100 Supplementation on Strength and Muscle Size in Middle-Aged Women,” 4th Asia-Pacific Conference on Exercise and Sport Science & 8th International Sports Science Conference 2009.

15. Henkel et al., “LJ100 Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors—A Pilot Study,” Phytother. Res. 28 (4), 544–550 (2014), Epub Jun 11, 2013.

16. George and Henkel, “Phytoandrogenic Properties of Eurycoma longifolia as Natural Alternative to Testosterone Replacement Therapy,” Andrologia. 46 (7), 708–721 (2014). doi: 10.1111/and.12214. Epub Jan 6, 2014.

17. Tambi et al, “[LJ100] Standardised Water-Soluble Extract of Eurycoma longifolia, Tongkat Ali, as Testosterone Booster For Managing Men With Late-Onset Hypogonadism?” First Int. J. Andrologia, 44 (1), 226–230 (2012). Epub 2011 Jun 15.

18. Faculty Abstract 11, The Aging Male 10 (2), 92 (2007).

19. Talbott et al., “Effect of a 6-Week Lifestyle Program on Mood State and Metabolic Parameters in Moderately Overweight Subjects,” Supplement Watch, Inc. and Treehouse Athletic Club, Salt Lake City, UT.

20. Talbott et al., “Effect of LJ100 on Stress Hormones and Psychological Mood State in Moderately Stressed Subjects,” J. Int. Society of Sports Nutr. 10 (1), 28 (2013).

21. George et al. “Antiviral Activity of a Standardized Root Water Extract of Eurycoma longifolia (LJ100I®) against Dengue Virus.” Poster presented at the International Conference of Natural Products, Bayview Beach Resort, Malaysia.

22. Han et al. “Antiinflammatory and analgesic effects of Eurycoma longifolia extracts” Arch. Pharm. Res. (2016) 39:421–428

23. Jayusman et al. “The Effects of Quassinoid-Rich Eurycoma longifolia Extract on Bone Turnover and Histomorphometry Indices in the Androgen-Deficient Osteoporosis Rat Model” Nutrients June 2018 2018, 10, 799; doi:10.3390/nu10070799

24. Thu et al. “Exploring molecular mechanism of bone-forming capacity of Eurycoma longifolia: Evidence of enhanced expression of bone-related biomarkers” J Ayurveda and Integ Med. “2017 1-11

25. Thu et al. “Eurycoma longifolia, a promising suppressor of RANKL-induced differentiation and activation of osteoclasts: An in vitro mechanistic evaluation” J Ayurveda and Integ Med. “2017 1-11

26. Imam et al. “Eurycoma Longifolia Jack Water Extract (Physta®) and its 4.3 Kilodalton Peptide Increase Insulin Secretion from Pancreatic Cells and Enhance Glucose Uptake in Insulin-Sensitive Cells, in Vitro” European Journal of Scientific Research 2017: 147 No 2 October 2017; 177-187

27. George et al. “Immunomodulation in Middle-Aged Humans Via the Ingestion of Standardized Root Water Extract of Eurycoma longifolia (LJ100®). PHYTOTHERAPY RESEARCH, Phytother. Res. (2016) Published online in Wiley Online Library

28. George et al. Efficacy and safety of Eurycoma longifolia (Physta®/LJ100®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study. Food & Nutrition Research 2018, 62: 1374

AstaReal® References

Skin Health

1. Tominaga K, Hongo N, Karato M, Yamashita E. Cosmetic benefits of astaxanthin on humans subjects. Acta Biochim Pol. 2012;59(1):43-7. Epub 2012 Mar 17. PMID: 22428137

2. Phetcharat L, Wongsuphasawat K, Winther K. The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity. Clin Interv Aging. 2015 Nov 19;10:1849-56. doi: 10.2147/CIA.S90092. PMID: 26604725; PMCID: PMC4655903.

Antioxidant Support

3. Hashimoto H, Arai K, Takahashi J, Chikuda M. The effect of aging on the antioxidative activity of astaxanthin in human aqueous humor. J Clin Biochem Nutr. 2021 Mar;68(2):169-172. doi: 10.3164/jcbn.20-87. Epub 2020 Sep 17. PMID: 33879969; PMCID: PMC8046000.

4. Hashimoto H, Arai K, Takahashi J, Chikuda M. Effects of astaxanthin on VEGF level and antioxidation in human aqueous humor: difference by sex. J Clin Biochem Nutr. 2019 Jul;65(1):47-51. doi: 10.3164/jcbn.18-110. Epub 2019 Apr 18. PMID: 31379413; PMCID: PMC6667389.

5. Hashimoto H, Arai K, Hayashi S, Okamoto H, Takahashi J, Chikuda M. The effect of astaxanthin on vascular endothelial growth factor (VEGF) levels and peroxidation reactions in the aqueous humor. J Clin Biochem Nutr. 2016 Jul;59(1):10-5. doi: 10.3164/jcbn.15-137. Epub 2016 May 21. PMID: 27499573; PMCID: PMC4933686.

6. Hashimoto H, Arai K, Hayashi S, Okamoto H, Takahashi J, Chikuda M, Obara Y. Effects of astaxanthin on antioxidation in human aqueous humor. J Clin Biochem Nutr. 2013 Jul;53(1):1-7. doi: 10.3164/jcbn.13-6. Epub 2013 May 18. PMID: 23874063; PMCID: PMC3705160.

Brain Health & Cognitive Function

7. Ito N, Saito H, Seki S, Ueda F, Asada T. Effects of Composite Supplement Containing Astaxanthin and Sesamin on Cognitive Functions in People with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2018;62(4):1767-1775. doi: 10.3233/JAD-170969. Erratum in: J Alzheimers Dis. 2019;68(2):839. PMID: 29614679; PMCID: PMC5900571.

8. Imai A, Oda Y, Ito N, Seki S, Nakagawa K, Miyazawa T, Ueda F. Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study. Nutrients. 2018 Feb 28;10(3):281. doi: 10.3390/nu10030281. PMID: 29495607; PMCID: PMC5872699.

Active Lifestyle, Muscle & Sports Performance

9. Baralic I, Andjelkovic M, Djordjevic B, Dikic N, Radivojevic N, Suzin-Zivkovic V, Radojevic-Skodric S, Pejic S. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. Evid Based Complement Alternat Med. 2015;2015:783761. doi: 10.1155/2015/783761. Epub 2015 Jun 18. PMID: 26167194; PMCID: PMC4488551.

10. Wong SK, Ima-Nirwana S, Chin KY. Effects of astaxanthin on the protection of muscle health (Review). Exp Ther Med. 2020 Oct;20(4):2941-2952. doi: 10.3892/etm.2020.9075. Epub 2020 Jul 29. PMID: 32855659; PMCID: PMC7444411.

Immune & Gut Health

11. Baralic I, Andjelkovic M, Djordjevic B, Dikic N, Radivojevic N, Suzin-Zivkovic V, Radojevic-Skodric S, Pejic S. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. Evid Based Complement Alternat Med. 2015;2015:783761. doi: 10.1155/2015/783761. Epub 2015 Jun 18. PMID: 26167194; PMCID: PMC4488551.

12. Park JS, Chyun JH, Kim YK, Line LL, Chew BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond). 2010 Mar 5;7:18. doi: 10.1186/1743-7075-7-18. PMID: 20205737; PMCID: PMC2845588.

13. Wu L, Lyu Y, Srinivasagan R, Wu J, Ojo B, Tang M, El-Rassi GD, Metzinger K, Smith BJ, Lucas EA, Clarke SL, Chowanadisai W, Shen X, He H, Conway T, von Lintig J, Lin D. Astaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice. J Nutr. 2020 Oct 12;150(10):2687-2698. doi: 10.1093/jn/nxaa222. PMID: 32810865; PMCID: PMC8023541.

Eye Health & Vision

14. Saito M, Yoshida K, Saito W, Fujiya A, Ohgami K, Kitaichi N, Tsukahara H, Ishida S, Ohno S. Astaxanthin increases choroidal blood flow velocity. Graefes Arch Clin Exp Ophthalmol. 2012 Feb;250(2):239-45. doi: 10.1007/s00417-011-1843-1. Epub 2011 Nov 10. PMID: 22072378.

Cardiovascular Health

14. Miyawaki H, Takahashi J, Tsukahara H, Takehara I. Effects of astaxanthin on human blood rheology. J Clin Biochem Nutr. 2008 Sep;43(2):69-74. doi: 10.3164/jcbn.2008048. PMID: 18818755; PMCID: PMC2533721.

15. Iwabayashi, M., Fujioka, N., Nomoto, K., Miyazaki, R., Takahashi, H., Hibino, S., Takahashi, Y., Nishikawa, K., Nishida, M., & Yonei, Y. (2009). Efficacy and safety of eight-week treatment with astaxanthin in individuals screened for increased oxidative stress burden. Anti-Aging Medicine, 6(4), 15–21. https://doi.org/10.3793/jaam.6.15

16. Tsukahara, H., Koikeda, T., Arai, T., Hayashi, H., Ohno, S., & Suzuki, N. (2008). Supplementation Effect of Astaxanthin on Blood Flow and Shoulder Stiffness -A Preliminary Pilot Study-. Japanese Journal of Complementary and Alternative Medicine. https://doi.org/10.1625/jcam.5.49

Pycnogenol® References

Skin Health, Anti-Aging, Beauty From Within 

1. Belcaro G, Luzzi R, Hu S, Cesarone MR, Dugall M, Ippolito E, Corsi M, Caporale S. Improvement in signs and symptoms in psoriasis patients with Pycnogenol® supplementation. Panminerva Med. 2014 Mar;56(1):41-8. PMID: 24637472.

2. Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J. Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin Pharmacol Physiol. 2012;25(2):86-92. doi: 10.1159/000335261. Epub 2012 Jan 21. PMID: 22270036.

3. Ni Z, Mu Y, Gulati O. Treatment of melasma with Pycnogenol. Phytother Res. 2002 Sep;16(6):567-71. doi: 10.1002/ptr.1085. PMID: 12237816.

4. Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, Watson RR, Packer L. Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med. 2001 Jan 15;30(2):154-60. doi: 10.1016/s0891-5849(00)00445-7. PMID: 11163532.

Brain Health & Cognitive Function, Neurological Support, Hearing 

5. Trebatická J, Kopasová S, Hradecná Z, Cinovský K, Skodácek I, Suba J, Muchová J, Zitnanová I, Waczulíková I, Rohdewald P, Duracková Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur Child Adolesc Psychiatry. 2006 Sep;15(6):329-35. doi: 10.1007/s00787-006-0538-3. Epub 2006 May 13. PMID: 16699814.

6. Grossi MG, Belcaro G, Cesarone MR, Dugall M, Hosoi M, Cacchio M, Ippolito E, Bavera P. Improvement in cochlear flow with Pycnogenol® in patients with tinnitus: a pilot evaluation. Panminerva Med. 2010 Jun;52(2 Suppl 1):63-7. PMID: 20657537.

7. Belcaro G, Luzzi R, Dugall M, Ippolito E, Saggino A. Pycnogenol® improves cognitive function, attention, mental performance and specific professional skills in healthy professionals aged 35-55. J Neurosurg Sci. 2014 Dec;58(4):239-48. Epub 2014 Mar 28. PMID: 24675223.

8. Belcaro G, Dugall M, Ippolito E, Hu S, Saggino A, Feragalli B. The COFU3 Study. Improvement in cognitive function, attention, mental performance with Pycnogenol® in healthy subjects (55-70) with high oxidative stress. J Neurosurg Sci. 2015 Dec;59(4):437-46. PMID: 26635191.

9. Luzzi R, Belcaro G, Zulli C, Cesarone MR, Cornelli U, Dugall M, Hosoi M, Feragalli B. Pycnogenol® supplementation improves cognitive function, attention and mental performance in students. Panminerva Med. 2011 Sep;53(3 Suppl 1):75-82. PMID: 22108481.

10. Ryan J, Croft K, Mori T, Wesnes K, Spong J, Downey L, Kure C, Lloyd J, Stough C. An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. J Psychopharmacol. 2008 Jul;22(5):553-62. doi: 10.1177/0269881108091584. PMID: 18701642.

Cardiovascular Health: Heart, Veins, Blood Pressure, Circulation, Endothelium, Nitric Oxide

11. Arcangeli P. Pycnogenol in chronic venous insufficiency. Fitoterapia. 2000 Jun;71(3):236-44. doi: 10.1016/s0367-326x(99)00164-1. PMID: 10844161.

12. Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Ruffini I, Fano F, Hosoi M. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol. Angiology. 2005 Nov-Dec;56(6):699-705. doi: 10.1177/000331970505600607. PMID: 16327946.

13. Belcaro G, Dugall M, Luzzi R, Ippolito E, Cesarone MR. Postpartum Varicose Veins: Supplementation with Pycnogenol or Elastic Compression-A 12-Month Follow-Up. Int J Angiol. 2017 Mar;26(1):12-19. doi: 10.1055/s-0033-1363784. Epub 2014 May 29. PMID: 28255210; PMCID: PMC5330748.

14. Belcaro G. A Clinical Comparison of Pycnogenol, Antistax, and Stocking in Chronic Venous Insufficiency. Int J Angiol. 2015 Dec;24(4):268-74. doi: 10.1055/s-0035-1556060. Epub 2015 Jul 15. PMID: 26648668; PMCID: PMC4656166.

15. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Acerbi G, Cacchio M, Di Renzo A, Hosoi M, Stuard S, Corsi M. Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study. Angiology. 2006 Oct-Nov;57(5):569-76. doi: 10.1177/0003319706291392. Erratum in: Angiology. 2008 Jun-Jul;59(3):385. PMID: 17067979.

16. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Acerbi G, Cacchio M, Di Renzo A, Hosoi M, Stuard S, Corsi M. Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study. Clin Appl Thromb Hemost. 2006 Apr;12(2):205-12. doi: 10.1177/107602960601200209. PMID: 16708123.

17. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Ippolito E, Fano F, Dugall M, Cacchio M, Di Renzo A, Hosoi M, Stuard S, Corsi M. Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study. Phytomedicine. 2010 Sep;17(11):835-9. doi: 10.1016/j.phymed.2010.04.009. Epub 2010 Jun 25. PMID: 20579863.

18. Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. Phytother Res. 2002 Mar;16 Suppl 1:S1-5. doi: 10.1002/ptr.1010. PMID: 11933130.

19. Petrassi C, Mastromarino A, Spartera C. PYCNOGENOL in chronic venous insufficiency. Phytomedicine. 2000 Oct;7(5):383-8. doi: 10.1016/S0944-7113(00)80059-8. PMID: 11081989.

20. Riccioni C, Sarcinella R, Izzo A, Palermo G, Liguori M. Efficacia della Troxerutina associata al Pycnogenol nel trattamento farmacologico dell’insufficienza venosa [Effectiveness of Troxerutin in association with Pycnogenol in the pharmacological treatment of venous insufficiency]. Minerva Cardioangiol. 2004 Feb;52(1):43-8. Italian. PMID: 14765037.

21. Schmidtke I, Schoop W. Pycnogenol—stasis edema and its medical treatment [in German]. Z Ganzheits Med. 1995;3:114-115.

22. Belcaro G, Cesarone MR, Rohdewald P, Ricci A, Ippolito E, Dugall M, Griffin M, Ruffini I, Acerbi G, Vinciguerra MG, Bavera P, Di Renzo A, Errichi BM, Cerritelli F. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost. 2004 Oct;10(4):373-7. doi: 10.1177/107602960401000410. PMID: 15497024.

23. Errichi BM, Belcaro G, Hosoi M, Cesarone MR, Dugall M, Feragalli B, Bavera P, Hosoi M, Zulli C, Corsi M, Ledda A, Luzzi R, Ricci A. Prevention of post thrombotic syndrome with Pycnogenol® in a twelve month study. Panminerva Med. 2011 Sep;53(3 Suppl 1):21-7. PMID: 22108473.

24. Rodriguez P, Belcaro G, Dugall M, Hu S, Luzzi R, Ledda A, Ippolito E, Corsi M, Ricci A, Feragalli B, Cornelli U, Gizzi C, Hosoi M. Recurrence of retinal vein thrombosis with Pycnogenol® or Aspirin® supplementation: a registry study. Panminerva Med. 2015 Sep;57(3):121-5. PMID: 25971329.

25. Belcaro G, Cesarone MR, Ricci A, Cornelli U, Rodhewald P, Ledda A, Di Renzo A, Stuard S, Cacchio M, Vinciguerra G, Gizzi G, Pellegrini L, Dugall M, Fano F. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol. Clin Appl Thromb Hemost. 2006 Oct;12(4):440-4. doi: 10.1177/1076029606292248. PMID: 17000888.

26. Cesarone MR, Belcaro G, Stuard S, Schönlau F, Di Renzo A, Grossi MG, Dugall M, Cornelli U, Cacchio M, Gizzi G, Pellegrini L. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants–a controlled study. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):41-6. doi: 10.1177/1074248409356063. Epub 2010 Jan 22. PMID: 20097689.

27. A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patients. (n.d.). University of Arizona. https://experts.arizona.edu/en/publications/a-randomized-double-blind-placebo-controlled-prospective-16-week-/fingerprints/

28. Liu X, Wei J, Tan F, Zhou S, Würthwein G, Rohdewald P. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004 Jan 2;74(7):855-62. doi: 10.1016/j.lfs.2003.07.037. PMID: 14659974.

29. Stuard S, Belcaro G, Cesarone MR, Ricci A, Dugall M, Cornelli U, Gizzi G, Pellegrini L, Rohdewald PJ. Kidney function in metabolic syndrome may be improved with Pycnogenol®. Panminerva Med. 2010 Jun;52(2 Suppl 1):27-32. PMID: 20657531.

30. Hu S, Belcaro G, Cornelli U, Luzzi R, Cesarone M, Dugall M, Feragalli B, Errichi B, Ippolito E, Grossi M, Hosoi M, Gizzi G, Trignani M. Effects of Pycnogenol® on endothelial dysfunction in borderline hypertensive, hyperlipidemic, and hyperglycemic individuals: the borderline study. Int Angiol. 2015 Feb;34(1):43-52. Epub 2014 Nov 13. PMID: 25391252.

31.) Belcaro G, Cornelli U, Luzzi R, Cesarone MR, Dugall M, Feragalli B, Errichi S, Ippolito E, Grossi MG, Hosoi M, Cornelli M, Gizzi G. Pycnogenol® supplementation improves health risk factors in subjects with metabolic syndrome. Phytother Res. 2013 Oct;27(10):1572-8. doi: 10.1002/ptr.4883. Epub 2013 Jan 28. PMID: 23359520.

Inflammation Response, Immune Function, Respiratory Health, Lung Function, Allergy & Sinus

32. Belcaro G, Luzzi R, Cesinaro Di Rocco P, Cesarone MR, Dugall M, Feragalli B, Errichi BM, Ippolito E, Grossi MG, Hosoi M, Errichi S, Cornelli U, Ledda A, Gizzi G. Pycnogenol® improvements in asthma management. Panminerva Med. 2011 Sep;53(3 Suppl 1):57-64. PMID: 22108478.

33. Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR. Pycnogenol((R)) in the Management of Asthma. J Med Food. 2001 Winter;4(4):201-209. doi: 10.1089/10966200152744472. PMID: 12639402.

34. Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 2004;41(8):825-32. doi: 10.1081/jas-200038433. PMID: 15641632.

35. Wilson D, Evans M, Guthrie N, Sharma P, Baisley J, Schonlau F, Burki C. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 2010 Aug;24(8):1115-9. doi: 10.1002/ptr.3232. PMID: 20549654.

36. Otorinolaringologia 2013 September;63(3):151-61. (n.d.). https://www.minervamedica.it/en/journals/Otorhinolaryngology/article.php?cod=R27Y2013N03A0151

37. Belcaro G, Cesarone MR, Genovesi D, Ledda A, Vinciguerra G, Ricci A, Pellegrini L, Gizzi G, Ippolito E, Dugall M, Cacchio M, Di Renzo A, Stuard S. Pycnogenol may alleviate adverse effects in oncologic treatment. Panminerva Med. 2008 Sep;50(3):227-34. PMID: 18927527.

Blood Sugar, Glucose Metabolism, & Kidney Function

38. Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Gizzi G, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M. Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol. Clin Appl Thromb Hemost. 2006 Jul;12(3):318-23. doi: 10.1177/1076029606290133. PMID: 16959685.

39. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, Ricci A, Gizzi G, Ippolito E, Fano F, Dugall M, Cipollone G, Acerbi G, Cacchio M, Del Boccio G, Di Renzo A, Stuard S, Corsi M. Improvement of diabetic microangiopathy with pycnogenol: A prospective, controlled study. Angiology. 2006 Aug-Sep;57(4):431-6. doi: 10.1177/0003319706290318. PMID: 17022378.

40. Liu X, Wei J, Tan F, Zhou S, Würthwein G, Rohdewald P. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci. 2004 Oct 8;75(21):2505-13. doi: 10.1016/j.lfs.2003.10.043. PMID: 15363656.

41. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care. 2004 Mar;27(3):839. doi: 10.2337/diacare.27.3.839. PMID: 14988316.

42. Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008 May;28(5):315-20. doi: 10.1016/j.nutres.2008.03.003. PMID: 19083426.

Joint Health

43. Belcaro G, Cesarone MR, Errichi S, Zulli C, Errichi BM, Vinciguerra G, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Errichi S, Gizzi G, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M, Rohdewald P. Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspects. Phytother Res. 2008 Apr;22(4):518-23. doi: 10.1002/ptr.2376. PMID: 18386255.

44. Cisár P, Jány R, Waczulíková I, Sumegová K, Muchová J, Vojtassák J, Duraćková Z, Lisý M, Rohdewald P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother Res. 2008 Aug;22(8):1087-92. doi: 10.1002/ptr.2461. PMID: 18570266.

45. A randomized, double-blind, placebo-controlled, prospective, 16 week crossover study to determine the role of Pycnogenol in modifying blood pressure in mildly hypertensive patients. (n.d.). University of Arizona. https://experts.arizona.edu/en/publications/a-randomized-double-blind-placebo-controlled-prospective-16-week-/fingerprints/

Eye Health

46. Spadea L, Balestrazzi E. Treatment of vascular retinopathies with Pycnogenol. Phytother Res. 2001 May;15(3):219-23. doi: 10.1002/ptr.853. PMID: 11351356.

Active Lifestyle & Sports Performance

47. Vinciguerra G, Belcaro G, Cesarone MR, Rohdewald P, Stuard S, Ricci A, Di Renzo A, Hosoi M, Dugall M, Ledda A, Cacchio M, Acerbi G, Fano F. Cramps and muscular pain: prevention with pycnogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy. Angiology. 2006 May-Jun;57(3):331-9. doi: 10.1177/000331970605700309. PMID: 16703193.

Oral Care

48. Kimbrough C, Chun M, dela Roca G, Lau BH. PYCNOGENOL chew-ing gum minimizes gingival bleeding and plaque formation. Phytomedicine. 2002;9(5):410-413.

Men’s Health

49. D̆Uračková, Z. (2003). Lipid metabolism and erectile function improvement by pycnogenol®, extract from the bark of pinus pinaster in patients suffering from erectile dysfunction-a pilot study. AGRIS: International Information System for the Agricultural Science and Technology. https://agris.fao.org/agris-search/search.do?recordID=US201600076652

Women’s Health

50. Errichi S, Bottari A, Belcaro G, Cesarone MR, Hosoi M, Cornelli U, Dugall M, Ledda A, Feragalli B. Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition. Panminerva Med. 2011 Sep;53(3 Suppl 1):65-70. PMID: 22108479.

51. Kohama T, Negami M. Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial. J Reprod Med. 2013 Jan-Feb;58(1-2):39-46. PMID: 23447917.

52. Maia H Jr, Haddad C, Casoy J. Combining oral contraceptives with a natural nuclear factor-kappa B inhibitor for the treatment of endometriosis-related pain. Int J Womens Health. 2013 Dec 21;6:35-9. doi: 10.2147/IJWH.S55210. PMID: 24379702; PMCID: PMC3873204.

53. Maia H Jr, Haddad C, Casoy J. The effect of pycnogenol on patients with dysmenorrhea using low-dose oral contraceptives. Int J Womens Health. 2014 Dec 11;6:1019-22. doi: 10.2147/IJWH.S75389. PMID: 25525393; PMCID: PMC4266261.

54. Yang HM, Liao MF, Zhu SY, Liao MN, Rohdewald P. A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women. Acta Obstet Gynecol Scand. 2007;86(8):978-85. doi: 10.1080/00016340701446108. PMID: 17653885.

55. Kohama T, Suzuki N, Ohno S, Inoue M. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea: an open clinical trial. J Reprod Med. 2004 Oct;49(10):828-32. PMID: 15568408.

56. Suzuki N, Uebaba K, Kohama T, Moniwa N, Kanayama N, Koike K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study. J Reprod Med. 2008 May;53(5):338-46. PMID: 18567279.

57. Kohama T, Herai K, Inoue M. Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate. J Reprod Med. 2007 Aug;52(8):703-8. PMID: 17879831.

58. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res. 2006 Mar;20(3):232-4. doi: 10.1002/ptr.1840. PMID: 16521117.

Hemorrhoid Support

59. Belcaro G, Gizzi G, Pellegrini L, Dugall M, Luzzi R, Corsi M, Ippolito E, Ricci A, Cesarone MR, Ledda A, Bottari A, Errichi BM. Pycnogenol® in postpartum symptomatic hemorrhoids. Minerva Ginecol. 2014 Feb;66(1):77-84. PMID: 24569406.

Edema on Long Flights

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