ac-11® + AstaReal® Bundle
Look and Feel Your Best with Patented Ingredients that Reverse Aging, Protect your Eyes, and Rejuvenate Your Skin at the Cellular Level.
Advanced DNA Repair? Enhanced Mitochondrial Function? Lower Oxidative Stress? Our Bundle has it all. Get patented ingredients you cant trust for a healthier you. Order now.
Lab Tested | Gluten free | Non-GMO | Junk Free
Choose options
Get Healthy from the Inside Out!
Combat Accelerated Aging and Promote Beauty from Within with Two of World’s Most Trusted and Versatile Ingredients, ac-11® and AstaReal®.
Benefits at a glance:
- DNA Repair & Telomere Health: Supports your body’s natural ability to repair DNA and maintain optimal telomere length and integrity during cellular mitosis.
- Youthful Skin: Enhances natural collagen production and reduces oxidative stress to reduce wrinkles, inflammation, and improve skin elasticity for a soft, supple, and youthful-looking complexion.
- Internal Sunscreen: Safeguard your skin from daily UV exposure.
- Eye Health: Protect your eyes from daily exposure to blue light emitted by smart devices, TVs, and computer screens.
- Brain Health: Boosts memory, mental agility, and multitasking abilities while restoring neural function from damage caused by high-decibel noise.
- Immune Boosting Power: Strengthens your immune system by increasing the life cycle of white blood cells and protecting them from oxidative stress.
- Heart Health: Improves cardiovascular health by enhancing blood flow, lowering oxidative stress and inflammation, and promoting a healthy blood lipid profile for optimal heart function.
- Digestive Health: Promotes gastric health by relieving gastrointestinal discomfort, protecting against stomach ulcers, and balancing the gut microbiome for improved digestion and overall wellness.
Bundle Overview:
What are ac-11® and AstaReal®?
Looking for a way to turn back the clock and look and feel your best? Meet the ac-11® + AstaReal® Bundle – the powerful duo that can help you achieve just that. With ac-11®’s patented extract of Uncaria Tomentosa inner bark and AstaReal®’s potent antioxidant support, you can say goodbye to accelerated aging and hello to beautiful, glowing skin.
But that’s not all – ac-11® has been validated by 42 published clinical studies on collagen health, immune health, and longevity, making it the only ingredient shown to help your body repair its DNA. And AstaReal®? It’s backed by 250 clinical studies (70 human clinical trials) , which demonstrate its all-system support, from promoting a healthy response to inflammation to boosting immune function, enhancing circulation and heart health, increasing muscle endurance, sharpening vision, and supporting GI health.
With ac-11® and AstaReal® working together, you can be sure that you’re getting the very best in science-based ingredients. Ac-11® helps rejuvenate your DNA and maintain the health of your telomeres, while AstaReal® bolsters your body’s antioxidant defenses, inhibiting free-radical activity that can affect cells, tissue, organs, and even DNA. So why settle for ordinary supplements when you can have Proof Vitality’s ac-11® + AstaReal® bundle? Try it today and see the difference for yourself.
Why Should I Get the ac-11® + AstaReal® Bundle?
The ac-11® + AstaReal® Bundle is a combination of two natural supplements that offer numerous benefits to the body. Ac-11® is backed by 42 clinical studies and has been found to support DNA repair, immune function, cognitive health, and collagen production, among other things. It helps reverse aging at the cellular level by repairing damaged DNA, reducing inflammation, and boosting immune function. It can also help with skin elasticity, promote healthy inflammation response, and repair neural damage. Studies suggest that a dosage of up to 700mg may be effective in fighting the aging process.
AstaReal® is a natural astaxanthin supplement that has been clinically researched for over 30 years. It supports healthy muscle function, vascular health, collagen support, and skin health. It provides powerful antioxidant protection to all layers of the skin, reduces oxidative stress, and enhances skin elasticity by strengthening the layers of collagen. AstaReal® also improves memory, mental quickness, multitasking, and learning in seniors reporting age-related forgetfulness. It can enhance vascular endothelial health, balance and strengthen the immune system, and boost antibody production.
Whether you’re looking to improve your skin’s appearance, boost your immune system, repair your DNA, or support your body’s natural defenses against aging, the ac-11® + AstaReal® Bundle is a great choice.
Bundle Benefits:Want to take a deeper dive? Read on!
The ac-11® + AstaReal® Bundle includes two ingredients: ac-11® and AstaReal®. These patented ingredients have a long history of clinical research and have been studied in 192 clinical studies combined, including more than 70 human clinical trials.
Our convenient, one-a-day supplements deliver effective, science-based dosages to ensure potency, Our ac®-11 delivers 700 mg per capsule, while AstaReal® comes in at a full 12 mg per serving.
When taken daily, these 2 powerful supplements offer more than 11 health benefits that can help combat accelerated aging, boost performance, and promote beauty from within for women and men.
Anti-Aging & Health Span
Our Anti Aging Beauty Bundle is much more than an advanced solution for skin care. We chose ac-11® because it not only helps your body repair its DNA but optimizes cellular health by promoting apoptosis (the clearing out of damaged cells). After all, it is the increase and accumulation of damaged cells (senescent cells) as we get older that causes accelerated aging and disease. AstaReal® helps your body scavenge for free radicals and promotes blood flow to keep you feeling and performing your best.
- Supports your body’s natural ability to repair its DNA
- Maintains telomere length and integrity during cellular division
- Promotes apoptosis (Our body’s ability to clear out damaged cells)
Antioxidant & Blood Sugar
AstaReal® Astaxanthin is one of nature’s most potent free radical scavengers, having 6000x the potency of vitamin-C.
- Promotes healthy blood sugar levels already in the normal range
- Inhibits free-radical activity
Brain & Cognitive Function
AstaReal® has positive physiological effects on the brain. Randomized double-blind, placebo-controlled studies have demonstrated that 3-months of supplementation with our patented natural astaxanthin extract (12mg/daily) boosted blood flow, improved memory, and mental quickness, and also improved multitasking and accelerated learning in seniors.
- Improve memory, alertness, multitasking, and age-related forgetfulness
- Lower the oxidation of red blood cells, boosting brain health
- Increase capillary blood flow and blood antioxidant quality
Collagen, Hair, Nails, & Skin
The skin is the largest organ of the body and is extremely complex. It’s made up of multiple layers – each performing unique and important functions. ac-11® and AstaReal® offers several proven benefits for your skin. Studies demonstrate ac-11® significantly boosts the natural production of type-III collagen in cutaneous tissue during periods of sun exposure. Type 3 collagen is what gives youthful skin its suppleness and elasticity.
AstaReal® natural astaxanthin helps to optimize the health and radiance of your skin by delivering powerful protection and support to all layers.
- Boosts Type-III collagen production
- Reinvigorates photoaged skin
- Soothes inflammation in all layers of skin
- Reduces the size of wrinkles
- Improves skin microtexture
DNA Repair & Telomere Health
ac-11® helps support DNA repair. The health of our cells, specifically repairing our DNA from daily damage, is believed to be a critical factor in combating accelerated aging.
Environmental factors such as pollution, ultraviolet radiation from the sun, electromagnetic radiation from our smart devices, polluted water, GMOs, and processed foods cause damage to our cells and DNA. Serious diseases, such as cancer are associated with damage to your cells and DNA due to these factors.
Our cells protect our DNA from damage with antioxidants. The body repairs or eliminated damaged cells by design through a natural process called apoptosis. When cellular DNA damage outpaces the body’s ability to repair it, physical signs of aging increase while quality of life decreases. Studies suggest a dosage of up to 700 mg of ac-11® daily may help your body defend against the natural aging process.
- Supports the body’s natural ability to repair its DNA combating accelerated aging
- Maintains telomere length and integrity during cellular mitosis
- Promotes apoptosis (our body’s ability to clear out damaged cells)
Digestion & GI Health
Gut health is the foundation for wellness, but the digestive system is the most sensitive organ in the human body. Clinical research has shown that supplementation with AstaReal® natural astaxanthin can promote gastric health by helping your body relieve gastrointestinal discomfort, protect against stomach ulcers, and balance the gut’s microbiome.
- Supports your body’s response to gastric inflammation
- Promotes microbial balance
- Eases digestive discomfort
Hearing & Vision Health
Maintaining vision and hearing is critical to healthy aging. ac-11® helps your body repair neural function caused by damage due to overexposure to high-decibel noise.
Numerous clinical studies have demonstrated that supplementation with AstaReal® astaxanthin can improve the discomfort linked to Computer Vision Syndrome, such as blurred vision, eye fatigue, and eye irritation. Research has also shown that AstaReal® supplementation improves eye fatigue by quenching cellular inflammation resulting from prolonged visual stress and ciliary muscle tension.
- Repairs neural function damaged by overexposure to high-decibel noise
- Combats computer eye strain and eye fatigue
- Supports accommodative function/dynamic focus.
- Provides antioxidant support for the eye.
- Promotes healthy blood flow to nourish eyes.
Heart, Veins & Circulation
Get Natural Cardiovascular Support with AstaReal®. A growing body of clinical research has shown that AstaReal® natural astaxanthin can help to improve cardiovascular health. Studies have demonstrated that our patented astaxanthin lowers oxidative stress and inflammation, enhances blood flow in capillaries and improves lipid profiles.
- Increases capillary circulation
- Promotes a healthy blood lipid profile
- Lowers oxidative stress
Immune Support
Several studies have shown that 700 mg daily of ac-11® may increase your white blood cell count and therefore enhance your immune response to combat infections and viruses. Other studies suggest it promotes a healthy response to inflammation, which may help to regulate your immune function, which may prevent your immune system from overreacting.
Like all of your body’s systems, the immune system functions better with added protection. AstaReal® significantly helps to balance and strengthen the immune system—improving its ability to defend the body against disease and illness and suppressing overactive immune responses that can result in undesirable inflammation.
- Promotes a faster immune response
- Balances and strengthens immune function
- Boosts antibody production
- Defends immune cells against oxidative stress
Inflammation Response
Studies demonstrate that ac-11® may help normalize the expression of the NF-kB factor in cells, therefore promoting a healthy response to inflammation. The normalization of the NF-kb factor supports apoptosis (your body’s programmed cell death) helping your body clear out damaged cells and promoting the replication of healthy cells.
- Promotes a healthy response to inflammation
Sports & Active Lifestyle
AstaReal® astaxanthin radically improves muscle endurance by supporting muscle function and boosting aerobic power. Our patented astaxanthin both scavenges for free radicals and improves your body’s response to inflammation. Studies show AstaReal® has also been found to lower lactic acid build-up and decrease fatigue.
- Improves muscle endurance and recovery
- Reduces lactic acid build-up and fatigue
- Decreases muscle damage and inflammation
- Enhances blood flow and improves the quality of red blood cells
- Increases fat metabolism by improving mitochondria function
- Boosts physical endurance
- Supports recovery from exercise
- Enhances the effect of exercise training
- Promotes fat utilization for sustained energy
- Supports mitochondrial function during physical activity
- Supports aging muscles
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Want to know more?
Frequently Asked Questions
AC-11® Cat's Claw Inner Bark Extract
ac-11® is a safe, all-natural, and highly-effective aqueous extract of Cat’s Claw (Uncaria tomentosa), a traditional medicinal plant indigenous to the Amazon rainforest. ac-11® is radically different than other cat’s claw exctracts since it is practically free of alkaloids. Standardized to a minimum 8% Carboxy Alkyl Esters (CAEs), research demonstrates ac-11®’s natural ability to help the body repair its DNA. Additional studies have also shown ac-11®’s ability to: support your body’s inflammation response, help rid the body of damaged cells, enhance immune function, and decrease the rate of telomere truncation.
Yes. Currently, ac-11® is backed by 42 clinical studies demonstrating its efficacy in oral and topical applications.
DNA (deoxyribonucleic acid) is the self-replicating molecule containing the genetic instructions for the functioning, development, growth, and reproduction of nearly all living organisms.
Absolutely. DNA contains genetic instructions driving all processes within the body and is critical to the optimal functioning of all cells within the body. Damage to DNA results in cellular mutation, resulting in the inefficient functioning of critical biological processes within the body. Evidence has shown that DNA damage is a key contributor to accelerated aging and may be linked to age-onset disease.
Natural DNA Repair is driven by several enzymatic processes that clear the damage caused to our DNA by oxidative and non-oxidative stress. Genetic integrity and cellular function are optimized and preserved by the homeostatic processes involved in natural DNA repair – keeping your body in its natural equilibrium. Consequently, the better our DNA repair processes work, the longer and healthier our lives can be.
Aging is the natural time-related deterioration of the body’s biological functions necessary to efficiently clear cellular toxicity and repair damaged DNA. The accumulation of DNA damage results in signs of aging, such as wrinkled or sagging skin, cognitive decline, and weakened immune function.
Not absolutely. Our DNA does not mean that we will age exactly like our family members. It also doesn’t mean that we will necessarily suffer the same genetic-related diseases. We can avoid detrimental lifestyle and environmental hazards that may contribute to accelerated aging or trigger the onset of certain genetically-based diseases. Avoiding overexposure to the sun, cigarette smoking, excessive alcohol consumption, and exposure to toxic environmental pollutants to help reduce cellular damage. Eating a diet rich in antioxidants, managing daily stress, and supplementing nutritional intake in smart ways can help minimize damage to DNA that takes place every day and improve the built-in repair mechanisms in our cells.
However, the damage to cells and DNA that has already occurred cannot be repaired. ac-11® is the first and only known plant extract shown to improve your body’s DNA repair ability.
ac-11® helps your body’s natural ability to repair its DNA. ac-11® may activate critical DNA repair enzymes located on Chromosome 11 that facilitate the body’s natural DNA repair process.
Backed by 42 clinical studies (and counting), ac-11® has been shown to have numerous therapeutic benefits including but not limited to:
- Support the body’s natural ability to repair its DNA—combating accelerated aging
- Repair skin damage resulting from excessive exposure to the Sun
- Boost immune function by increasing the life cycle of white blood cells
- Repair neural function damage caused by overexposure to high-decibel noise
- Promote a healthy response to inflammation resulting in the down-regulation of pro-inflammatory cytokines
- Maintain telomere length and integrity during cellular mitosis
- Enhance the production of natural collagen III—a form of collagen associated with soft, supple, youthful-looking skin
Lab Tested | Gluten free | Non-GMO | Junk Fee
ac-11® is the only known extract of Uncaria tomentosa that helps the body repair its DNA. This therapeutic claim is demonstrated by 42 clinical studies and a variety of patents. ac-11® has a distinctly low-weight, alkaloid-free molecular composition that’s extremely small (less than 10,000 Daltons) and is highly bioavailable due to its patented ultra-filtration aqueous extraction process. As a result, ac-11® is safe, pure, and effective for long-term use.
Contrarily, the other generic “cat’s claw” extracts on the market are not grounded in research. They are most are water-insoluble, alkaloid-based extracts and are shown to be mildly toxic with long-term use.
ac-11® is produced in an ISO 9002-Certified Facility operated under strict FDA regulations and GMP (Good Manufacturing Practices) standards. Lab Tested, ac-11® adheres to all accepted industry standards to ensure the safety, purity, and efficacy of every batch.
Yes. ac-11® consumption has been proven to be safe at any amount less than 8,000mg. The recommended daily dose of ac-11® is 350 to 700mg for adults weighing between 120 and 200 pounds (70-90 kg).
We recommend consulting your healthcare practitioner is you are pregnant, nursing or on medication. However, ac-11® does not negatively interact with common pharmaceuticals and is safe to take with other medications as has been demonstrated by CYP analysis.
Yes. ac-11® has 11 patents protecting its technology, composition, active ingredients, and numerous health benefits.
No. ac-11® and its carrier, Manioc Maltodextrin, are all-natural.
Yes. ac-11® is made in full cooperation with the Floravida Institutes of Brazil’s guidelines for biodiversity, environmental education, conservation, and local community social inclusion. ac-11®, extracted from the inner bark of Cat’s Claw (Uncaria tomentosa), is sustainably harvested around three feet above the ground to maintain the plant’s health. Then, to further promote the integrity of the root structure and to stimulate rapid regeneration of the vine, the plant is capped. Finally, new Cat’s Claw seedlings are carefully planted in the harvesting zone to ensure continued viability.
AstaReal® Natural Astaxanthin Extract
AstaReal® is a patented extract of the aquatic carotenoid, natural astaxanthin, and is the only evidence-based, non-synthetic astaxanthin extract
Yes, AstaReal®, the patented extract of natural astaxanthin is the subject of 150 clinical studies and 70 human clinical trials showing its versatility as a tool for health optimization with several benefits.
Yes, AstaReal is produced in the USA in a cGMP (Good Manufacturing Practice) facility.
No. Proof Vitality only uses AstaReal®, a lab-tested, natural extract of astaxanthin.Other brands cut costs using synthetic astaxanthin produced from petrochemicals through chemical synthesis. But the natural astaxanthin found in nature, produced by algae and other organisms, is safer and more effective.
The key difference between the two forms is that over 95% of natural astaxanthin molecules are esterified, allowing it to protect your cell membranes in ways synthetic astaxanthin cannot.
Additionally, natural astaxanthin has potentially higher bioavailability and more biological functions, making it preferable for supplementation. As awareness about its health benefits continues to grow, the demand for natural astaxanthin is skyrocketing due to its proven safety and efficacy.
AstaReal® Astaxanthin offers a range of health benefits for overall well-being. Its ability to balance and strengthen the immune system leads to a faster immune response and an enhanced response to inflammation.
Our natural astaxanthin also improves muscle endurance, brain health, vision, digestive function, skin health, and cardiovascular function by reducing inflammation, improving blood flow, and decreasing oxidative stress.
AstaReal® Astaxanthin offers versatile support for a healthy lifestyle with several clinically demonstrated benefits.
AstaReal® Astaxanthin is a premium-quality supplement sourced from non-GMO Haematococcus pluvialis freshwater microalgae. To create this product, the best astaxanthin-producing cells were selectively bred from hand-selected original cells. The microalgae are cultivated in indoor bioreactors under carefully controlled conditions that include optimal lighting and nutrition for each growth phase. This sophisticated biotechnology is exclusive to AstaReal® and sets itself apart from the competitors, who cannot easily replicate this patented process.
AstaReal® is produced in a facility that has received GMP registration from NSF International, indicating compliance with FDA regulations for manufacturing dietary supplements.Adhering to GMP guidelines ensures consistent production and labeling and is the gold standard of high-quality products.
AstaReal® has over 30 years of R&D and been studied in over 70 human clinical studies, revealing various health benefits. Additionally, it’s undergone over 40 safety studies with no reported adverse events
Yes. AstaReal® is the leader in astaxanthin patents for both human and animal health.
No. AstaReal® does not contain synthetic ingredients.
At present, our astaxanthin extract is vegan, but our softgels are not vegan. We currently use softgels, because have been demonstrated to effectively preserve the quality and integrity of the oil. However, we are actively seeking a vegan alternative that will not compromise the natural astaxanthin extract that we use.
Yes. AstaReal® is a high-quality natural astaxanthin extract produced safely and sustainably under strict food safety guidelines that include thorough hazard assessments. Additionally, all suppliers and sub-contractors must meet AstaReal®’s standards for social responsibility, climate, environment, and governance. Furthermore, AstaReal® purchases climate-neutral and environmentally certified green electricity from hydropower to reduce their carbon footprint.
References
ac-11® References
DNA Repair, Cellular Health, Anti Aging, Life Span, & Health Span
1. Sheng Y, Li L, Holmgren K, Pero RW. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001 Jul;8(4):275-82. doi: 10.1078/0944-7113-00045. PMID: 11515717.
2. Pero, R. W., Hoppe, C., & Sheng, Y. (2000). Serum Thiols as a Surrogate Estimate of DNA Repair Correlates to Mammalian Life Span. Journal of Anti-Aging Medicine. https://doi.org/10.1089/rej.1.2000.3.241
3. Banne AF, Amiri A, Pero RW. Reduced level of serum thiols in patients with a diagnosis of active disease. J Anti Aging Med. 2003;6(4):327-34. doi: 10.1089/109454503323028920. PMID: 15142434.
4. Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 2012 Jul;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18. PMID: 22706308; PMCID: PMC3386805.
5. Akesson Ch, Pero RW, Ivars F. C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine. 2003 Jan;10(1):23-33. doi: 10.1078/094471103321648629. PMID: 12622460.
6. Pero RW, Amiri A, Sheng Y, Welther M, Rich M. Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements. Phytomedicine. 2005 Apr;12(4):255-63. doi: 10.1016/j.phymed.2004.01.008. PMID: 15898702.
7. Pero, R. W., Giampapa, V. C., & Vojdani, A. (2002). Comparison of a Broad Spectrum Anti-Aging Nutritional Supplement with and without the Addition of a DNA Repair Enhancing Cat’s Claw Extract. Journal of Anti-Aging Medicine. https://doi.org/10.1089/109454502763485467
8.Pero, R. W. (2009, September 1). In vivo treatment of humans with quinic acid enhances DNA repair and reduces the influence of lifestyle factors on risk to disease. Document – Gale Academic OneFile. https://go.gale.com/ps/i.do?id=GALE%7CA215925274&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=09732691&p=AONE&sw=w&userGroupName=anon%7E6ddd846
9. Guthrie OW. Dynamic compartmentalization of DNA repair proteins within spiral ganglion neurons in response to noise stress. Int J Neurosci. 2012 Dec;122(12):757-66. doi: 10.3109/00207454.2012.721828. Epub 2012 Oct 16. PMID: 22900489.
Immune Health, Inflammation Response, Apoptosis, & Cellular Senescence
10. Sheng Y, Pero RW, Amiri A, Bryngelsson C. Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Res. 1998 Sep-Oct;18(5A):3363-8. PMID: 9858909.
11. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000 Feb;69(2):115-26. doi: 10.1016/s0378-8741(99)00070-7. PMID: 10687868.
12. Sheng Y, Pero RW, Wagner H. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000 Apr;7(2):137-43. doi: 10.1016/S0944-7113(00)80086-0. PMID: 10839217.
13. Lamm S, Sheng Y, Pero RW. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine. 2001 Jul;8(4):267-74. doi: 10.1078/0944-7113-00046. PMID: 11515716.
Brain Health, Neurological Support, Cognitive Function, Hearing
14. Guthrie OW, Gearhart CA, Fulton S, Fechter LD. Carboxy alkyl esters of Uncaria tomentosa augment recovery of sensorineural functions following noise injury. Brain Res. 2011 Aug 17;1407:97-106. doi: 10.1016/j.brainres.2011.06.044. Epub 2011 Jun 24. PMID: 21762882.
15. Guthrie, O. W., & Xu, H. (2013b). Reduced Phosphorylation of Histone Variant H2Ax in the Organ of Corti is Associated with Otoprotection from Noise Injury. Otolaryngology, 03(01). https://doi.org/10.4172/2161-119x.1000131
16. Guthrie OW. Preservation of Neural Sensitivity after Noise-Induced Suppression of Sensory Function. J Am Acad Audiol. 2016 Jan;27(1):49-61. doi: 10.3766/jaaa.15047. PMID: 26809326.
17. Shi Z, Lu Z, Zhao Y, Wang Y, Zhao-Wilson X, Guan P, Duan X, Chang YZ, Zhao B. Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model. Neurochem Int. 2013 Jun;62(7):940-7. doi: 10.1016/j.neuint.2013.03.001. Epub 2013 Mar 14. PMID: 23500604.
Safety, Efficacy, Functionality
18. Montoro P, Carbone V, Quiroz Jde D, De Simone F, Pizza C. Identification and quantification of components in extracts of Uncaria tomentosa by HPLC-ES/MS. Phytochem Anal. 2004 Jan-Feb;15(1):55-64. doi: 10.1002/pca.740. PMID: 14979528.
19. Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F. Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100. Int Immunopharmacol. 2005 Jan;5(1):219-29. doi: 10.1016/j.intimp.2004.09.028. PMID: 15589483.
20. Sheng Y, Akesson C, Holmgren K, Bryngelsson C, Giamapa V, Pero RW. An active ingredient of Cat’s Claw water extracts identification and efficacy of quinic acid. J Ethnopharmacol. 2005 Jan 15;96(3):577-84. doi: 10.1016/j.jep.2004.10.002. Epub 2004 Dec 8. PMID: 15619581.
21. Historical Development of Uncaria Preparations and Their Related bioactive Components. novapublishers.com.(Pero: Nova Sciences Publishers, Chapter 10, 2010)
22. McDonnell AM, Dang CH. Basic review of the cytochrome p450 system. J Adv Pract Oncol. 2013 Jul;4(4):263-8. doi: 10.6004/jadpro.2013.4.4.7. PMID: 25032007; PMCID: PMC4093435.
Antioxidant Potential
23. Brunswick Labs, Certificate of Analysis, ORAC Value results for ac-11®
24. Pero RW, Lund H, Leanderson T. Antioxidant metabolism induced by quinic acid. Increased urinary excretion of tryptophan and nicotinamide. Phytother Res. 2009 Mar;23(3):335-46. doi: 10.1002/ptr.2628. PMID: 18844285.
25. Pero RW, Lund H. Dietary quinic acid supplied as the nutritional supplement AIO + AC-11® leads to induction of micromolar levels of nicotinamide and tryptophan in the urine. Phytother Res. 2011 Jun;25(6):851-7. doi: 10.1002/ptr.3348. Epub 2010 Nov 22. PMID: 21104945.
AstaReal® References
Skin Health
1. Tominaga K, Hongo N, Karato M, Yamashita E. Cosmetic benefits of astaxanthin on humans subjects. Acta Biochim Pol. 2012;59(1):43-7. Epub 2012 Mar 17. PMID: 22428137
2. Phetcharat L, Wongsuphasawat K, Winther K. The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity. Clin Interv Aging. 2015 Nov 19;10:1849-56. doi: 10.2147/CIA.S90092. PMID: 26604725; PMCID: PMC4655903.
Antioxidant Support
3. Hashimoto H, Arai K, Takahashi J, Chikuda M. The effect of aging on the antioxidative activity of astaxanthin in human aqueous humor. J Clin Biochem Nutr. 2021 Mar;68(2):169-172. doi: 10.3164/jcbn.20-87. Epub 2020 Sep 17. PMID: 33879969; PMCID: PMC8046000.
4. Hashimoto H, Arai K, Takahashi J, Chikuda M. Effects of astaxanthin on VEGF level and antioxidation in human aqueous humor: difference by sex. J Clin Biochem Nutr. 2019 Jul;65(1):47-51. doi: 10.3164/jcbn.18-110. Epub 2019 Apr 18. PMID: 31379413; PMCID: PMC6667389.
5. Hashimoto H, Arai K, Hayashi S, Okamoto H, Takahashi J, Chikuda M. The effect of astaxanthin on vascular endothelial growth factor (VEGF) levels and peroxidation reactions in the aqueous humor. J Clin Biochem Nutr. 2016 Jul;59(1):10-5. doi: 10.3164/jcbn.15-137. Epub 2016 May 21. PMID: 27499573; PMCID: PMC4933686.
6. Hashimoto H, Arai K, Hayashi S, Okamoto H, Takahashi J, Chikuda M, Obara Y. Effects of astaxanthin on antioxidation in human aqueous humor. J Clin Biochem Nutr. 2013 Jul;53(1):1-7. doi: 10.3164/jcbn.13-6. Epub 2013 May 18. PMID: 23874063; PMCID: PMC3705160.
Brain Health & Cognitive Function
7. Ito N, Saito H, Seki S, Ueda F, Asada T. Effects of Composite Supplement Containing Astaxanthin and Sesamin on Cognitive Functions in People with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2018;62(4):1767-1775. doi: 10.3233/JAD-170969. Erratum in: J Alzheimers Dis. 2019;68(2):839. PMID: 29614679; PMCID: PMC5900571.
8. Imai A, Oda Y, Ito N, Seki S, Nakagawa K, Miyazawa T, Ueda F. Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study. Nutrients. 2018 Feb 28;10(3):281. doi: 10.3390/nu10030281. PMID: 29495607; PMCID: PMC5872699.
Active Lifestyle, Muscle & Sports Performance
9. Baralic I, Andjelkovic M, Djordjevic B, Dikic N, Radivojevic N, Suzin-Zivkovic V, Radojevic-Skodric S, Pejic S. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. Evid Based Complement Alternat Med. 2015;2015:783761. doi: 10.1155/2015/783761. Epub 2015 Jun 18. PMID: 26167194; PMCID: PMC4488551.
10. Wong SK, Ima-Nirwana S, Chin KY. Effects of astaxanthin on the protection of muscle health (Review). Exp Ther Med. 2020 Oct;20(4):2941-2952. doi: 10.3892/etm.2020.9075. Epub 2020 Jul 29. PMID: 32855659; PMCID: PMC7444411.
Immune & Gut Health
11. Baralic I, Andjelkovic M, Djordjevic B, Dikic N, Radivojevic N, Suzin-Zivkovic V, Radojevic-Skodric S, Pejic S. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. Evid Based Complement Alternat Med. 2015;2015:783761. doi: 10.1155/2015/783761. Epub 2015 Jun 18. PMID: 26167194; PMCID: PMC4488551.
12. Park JS, Chyun JH, Kim YK, Line LL, Chew BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond). 2010 Mar 5;7:18. doi: 10.1186/1743-7075-7-18. PMID: 20205737; PMCID: PMC2845588.
13. Wu L, Lyu Y, Srinivasagan R, Wu J, Ojo B, Tang M, El-Rassi GD, Metzinger K, Smith BJ, Lucas EA, Clarke SL, Chowanadisai W, Shen X, He H, Conway T, von Lintig J, Lin D. Astaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice. J Nutr. 2020 Oct 12;150(10):2687-2698. doi: 10.1093/jn/nxaa222. PMID: 32810865; PMCID: PMC8023541.
Eye Health & Vision
14. Saito M, Yoshida K, Saito W, Fujiya A, Ohgami K, Kitaichi N, Tsukahara H, Ishida S, Ohno S. Astaxanthin increases choroidal blood flow velocity. Graefes Arch Clin Exp Ophthalmol. 2012 Feb;250(2):239-45. doi: 10.1007/s00417-011-1843-1. Epub 2011 Nov 10. PMID: 22072378.
Cardiovascular Health
14. Miyawaki H, Takahashi J, Tsukahara H, Takehara I. Effects of astaxanthin on human blood rheology. J Clin Biochem Nutr. 2008 Sep;43(2):69-74. doi: 10.3164/jcbn.2008048. PMID: 18818755; PMCID: PMC2533721.
15. Iwabayashi, M., Fujioka, N., Nomoto, K., Miyazaki, R., Takahashi, H., Hibino, S., Takahashi, Y., Nishikawa, K., Nishida, M., & Yonei, Y. (2009). Efficacy and safety of eight-week treatment with astaxanthin in individuals screened for increased oxidative stress burden. Anti-Aging Medicine, 6(4), 15–21. https://doi.org/10.3793/jaam.6.15
16. Tsukahara, H., Koikeda, T., Arai, T., Hayashi, H., Ohno, S., & Suzuki, N. (2008). Supplementation Effect of Astaxanthin on Blood Flow and Shoulder Stiffness -A Preliminary Pilot Study-. Japanese Journal of Complementary and Alternative Medicine. https://doi.org/10.1625/jcam.5.49